Physicochemical investigations of metolose coating films

G. Regdon, B. Zsellér, K. Pintye-Hódi

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

In the course of film coat preparation it is very important to carry out preformulation investigations. The film formed by Metolose® SM-4 polymer containing Macrogol 2000 (polyethylene glycol) as plasticizer showed structure changes depending on the concentration of the plasticizer during storage. This could be explained by the fact that the small quantity of plasticizer can be built in among the methyl cellulose molecules more easily, while the greater amount of plasticizer forms a separate phase in the beginning and can be built in into the film structure only later. On the other hand, the water bound by the hygroscopic property of the plasticizer can further influence the properties of the film as water also serves to function as a plasticizer. The increase in the quantity of the plasticizer enhanced the tensile strength of the film: the resulting film was less breakable and easier to handle mechanically. The studied films proved to be suitable for forming a protective coat of different solid dosage forms (pellets, tablets).

Original languageEnglish
Pages (from-to)581-594
Number of pages14
JournalComposite Interfaces
Volume17
Issue number5-7
DOIs
Publication statusPublished - Jul 1 2010

Keywords

  • DSC
  • Macrogol 2000
  • Metolose
  • coating films
  • mechanical properties
  • physical-chemical investigations
  • surface free energy

ASJC Scopus subject areas

  • Ceramics and Composites
  • Physics and Astronomy(all)
  • Surfaces, Coatings and Films

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