Physicochemical analysis in the evaluation of reconstituted dry emulsion tablets

Noémi Anna Niczinger, Barnabás Kállai-Szabó, Miléna Lengyel, Péter Gordon, I. Klebovich, I. Antal

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

The aim of this study was to characterize the formation of emulsions by droplet size analysis and turbidimetry during reconstitution from a solid dosage form, namely from dry emulsion systems, which carry an oil phase for poorly soluble active ingredients. For the dry emulsion systems tablets were prepared either from oil-in-water systems using a freeze-drying process or through direct compression containing the same oil and excipients. The ratios of oil to emulgents and oil to xanthan gum were equal in both methods. In the preparation methods applied, mannitol, erythritol and lactose were used as excipients and mannitol was found to be the most effective excipient based on droplet size reconstitution, turbidimetry and physical properties. Quality control involved testing the physical properties of tablets and characterizing the reconstituted emulsions.

Original languageEnglish
Pages (from-to)86-93
Number of pages8
JournalJournal of Pharmaceutical and Biomedical Analysis
Volume134
DOIs
Publication statusPublished - Feb 5 2017

    Fingerprint

Keywords

  • Contact angle
  • Laser diffraction
  • Olive oil
  • Required HLB
  • Scanning microscopy
  • Turbidimetry

ASJC Scopus subject areas

  • Analytical Chemistry
  • Pharmaceutical Science
  • Drug Discovery
  • Spectroscopy
  • Clinical Biochemistry

Cite this