Physico- chemical studies on solid dispersions of nifluminic acid prepared with PVP

Rita Ambrus, Z. Aigner, Cristina Dehelean, Codruţa Şoica, P. Szabó-Révész

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Nifluminic acid is an important anti-inflammatory drug with low aqueous solubility. In order to increase the degree of dissolution of nifluminic acid, products were prepared with polyvinylpyrrolidone (PVP) K-25, using physical mixing and solvent evaporation methods. The solubilities of the products were characterized by means of dissolution and in vitro membrane diffusion from simulated media. The wettability properties of the pure ingredient and its products were determined, with registration of their contact angles. In contrast with the very poor solubility of pure nifluminic acid, the dispersion of the drug in the polymers considerably enhanced the dissolution. This can be attributed to the improved wettability and dispersibility, the particle size reduction and the decrease in the crystalline fraction of the drug.

Original languageEnglish
Pages (from-to)60-64
Number of pages5
JournalRevista de Chimie
Volume58
Issue number1
Publication statusPublished - Jan 2007

Fingerprint

Povidone
Dispersions
Dissolution
Solubility
Acids
Wetting
Pharmaceutical Preparations
Contact angle
Polymers
Evaporation
Anti-Inflammatory Agents
Particle size
Crystalline materials
Membranes

Keywords

  • Dissolution
  • Nifluminic acid
  • Polyvinylpyrrolidone
  • Solid dispersion

ASJC Scopus subject areas

  • Chemistry(all)
  • Chemical Engineering(all)

Cite this

Physico- chemical studies on solid dispersions of nifluminic acid prepared with PVP. / Ambrus, Rita; Aigner, Z.; Dehelean, Cristina; Şoica, Codruţa; Szabó-Révész, P.

In: Revista de Chimie, Vol. 58, No. 1, 01.2007, p. 60-64.

Research output: Contribution to journalArticle

Ambrus, Rita ; Aigner, Z. ; Dehelean, Cristina ; Şoica, Codruţa ; Szabó-Révész, P. / Physico- chemical studies on solid dispersions of nifluminic acid prepared with PVP. In: Revista de Chimie. 2007 ; Vol. 58, No. 1. pp. 60-64.
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