Physico-chemical profiling of antidepressive sertraline: Solubility, ionisation, lipophilicity

Katalin Deák, Krisztina Takács-Novaák, Károly Tihanyi, Béla Noszál

Research output: Contribution to journalArticle

21 Citations (Scopus)


The fundamental physico-chemical parameters of sertraline, a potent selective serotonin reuptake inhibitor and reference compound in the development of new antidepressive agents, were determined. The thermodynamic solubility of the hydrochloride salt (S = 4.24 ± 0.02 mg/ml) and the free base form (S ≈ 0.002 mg/ml) was measured by the saturation shake-flask method. The co-solvent technique in methanol/water mixtures and the Yasuda-Shedlovsky extrapolation were applied for the determination of the dissociation constant (pka = 9.16 ± 0.02). The partition of sertraline was studied in octanol/water and alkane/water systems determining the logPoct and logPch values by potentiometric and shake-flask methods, respectively. These experimental data were used to interpret the excellent pharmacokinetic properties of the molecule. The high lipophilicity value (logPoct = 4.30 ± 0.01) of the nonionised form confirms the good absorption and distribution in the body. However, the good brain penetration can better be explained with the lack of polar interactions evidenced here by the zero ΔlogP (logPoct - logPch) value of sertraline.

Original languageEnglish
Pages (from-to)385-389
Number of pages5
JournalMedicinal Chemistry
Issue number4
Publication statusPublished - Jul 1 2006


  • Pharmacokinetics
  • Physico-chemical profiling
  • Sertraline
  • logP
  • logS
  • pK

ASJC Scopus subject areas

  • Drug Discovery

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