Physical analysis of the molecular motions during transcription

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

A simple theoretical model is presented dealing with the mechanical motion of the bacterial DNA-dependent RNA polymerase during transcription. Derivation of a physical model, based on accepting the existence of a series of Michaelian-type complexes during the transcription, resulted in a contradiction with physical reality. In order to solve this energetic contradiction, a model is suggested regarding the polymerase as an elastic, fluctuating entity instead of a quasi-rigid sphere.

Original languageEnglish
Pages (from-to)175-180
Number of pages6
JournalJournal of Theoretical Biology
Volume67
Issue number1
DOIs
Publication statusPublished - Jul 7 1977

Fingerprint

Bacterial DNA
DNA-Directed RNA Polymerases
Transcription
Theoretical Models
Motion
physical models
DNA-directed RNA polymerase
Physical Model
Theoretical Model
Model-based
RNA
Series
Dependent
DNA
Model

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)

Cite this

Physical analysis of the molecular motions during transcription. / Somogyi, B.; Trón, L.; Damjanovich, S.

In: Journal of Theoretical Biology, Vol. 67, No. 1, 07.07.1977, p. 175-180.

Research output: Contribution to journalArticle

@article{2d4ab9c8e0c444f091beea636110fb8f,
title = "Physical analysis of the molecular motions during transcription",
abstract = "A simple theoretical model is presented dealing with the mechanical motion of the bacterial DNA-dependent RNA polymerase during transcription. Derivation of a physical model, based on accepting the existence of a series of Michaelian-type complexes during the transcription, resulted in a contradiction with physical reality. In order to solve this energetic contradiction, a model is suggested regarding the polymerase as an elastic, fluctuating entity instead of a quasi-rigid sphere.",
author = "B. Somogyi and L. Tr{\'o}n and S. Damjanovich",
year = "1977",
month = "7",
day = "7",
doi = "10.1016/0022-5193(77)90191-6",
language = "English",
volume = "67",
pages = "175--180",
journal = "Journal of Theoretical Biology",
issn = "0022-5193",
publisher = "Academic Press Inc.",
number = "1",

}

TY - JOUR

T1 - Physical analysis of the molecular motions during transcription

AU - Somogyi, B.

AU - Trón, L.

AU - Damjanovich, S.

PY - 1977/7/7

Y1 - 1977/7/7

N2 - A simple theoretical model is presented dealing with the mechanical motion of the bacterial DNA-dependent RNA polymerase during transcription. Derivation of a physical model, based on accepting the existence of a series of Michaelian-type complexes during the transcription, resulted in a contradiction with physical reality. In order to solve this energetic contradiction, a model is suggested regarding the polymerase as an elastic, fluctuating entity instead of a quasi-rigid sphere.

AB - A simple theoretical model is presented dealing with the mechanical motion of the bacterial DNA-dependent RNA polymerase during transcription. Derivation of a physical model, based on accepting the existence of a series of Michaelian-type complexes during the transcription, resulted in a contradiction with physical reality. In order to solve this energetic contradiction, a model is suggested regarding the polymerase as an elastic, fluctuating entity instead of a quasi-rigid sphere.

UR - http://www.scopus.com/inward/record.url?scp=0017382365&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0017382365&partnerID=8YFLogxK

U2 - 10.1016/0022-5193(77)90191-6

DO - 10.1016/0022-5193(77)90191-6

M3 - Article

C2 - 881867

AN - SCOPUS:0017382365

VL - 67

SP - 175

EP - 180

JO - Journal of Theoretical Biology

JF - Journal of Theoretical Biology

SN - 0022-5193

IS - 1

ER -