Physical analysis of the molecular motions during transcription

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Abstract

A simple theoretical model is presented dealing with the mechanical motion of the bacterial DNA-dependent RNA polymerase during transcription. Derivation of a physical model, based on accepting the existence of a series of Michaelian-type complexes during the transcription, resulted in a contradiction with physical reality. In order to solve this energetic contradiction, a model is suggested regarding the polymerase as an elastic, fluctuating entity instead of a quasi-rigid sphere.

Original languageEnglish
Pages (from-to)175-180
Number of pages6
JournalJournal of Theoretical Biology
Volume67
Issue number1
DOIs
Publication statusPublished - Jul 7 1977

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ASJC Scopus subject areas

  • Statistics and Probability
  • Modelling and Simulation
  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)
  • Agricultural and Biological Sciences(all)
  • Applied Mathematics

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