A simple theoretical model is presented dealing with the mechanical motion of the bacterial DNA-dependent RNA polymerase during transcription. Derivation of a physical model, based on accepting the existence of a series of Michaelian-type complexes during the transcription, resulted in a contradiction with physical reality. In order to solve this energetic contradiction, a model is suggested regarding the polymerase as an elastic, fluctuating entity instead of a quasi-rigid sphere.
ASJC Scopus subject areas
- Statistics and Probability
- Modelling and Simulation
- Biochemistry, Genetics and Molecular Biology(all)
- Immunology and Microbiology(all)
- Agricultural and Biological Sciences(all)
- Applied Mathematics