Physical activity, sedentary time, and liver enzymes in adolescents

The HELENA study

Jonatan R. Ruiz, Idoia Labayen, Francisco B. Ortega, Luis A. Moreno, Gerardo Rodriguez, Christina Breidenassel, Yannis Manios, Anthony Kafatos, D. Molnár, Stephaan De Henauw, Frederic Gottrand, Kurt Widhalm, Manuel J. Castillo, Michael Sjöström

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Background:To examine the association between physical activity (PA) and liver enzyme levels in adolescents from nine European countries.Methods:The study comprised 718 adolescents (397 girls). PA was measured by accelerometry and expressed as total PA (counts/min), and time (min/d) engaged in moderate to vigorous intensity PA (MVPA). Time spent sedentary was also objectively measured. We measured serum levels of alanine aspartate aminostrasferase (AST), alanine aminostransferase (ALT), and γ-glutamyltrasnferase (GGT), and the AST/ALT ratio was computed.Results:There was an association between MVPA and AST and AST/ALT (age, sex, and center-adjusted β = 0.096, 95% confidence interval (CI): 0.016 to 0.118; and β = 0.090, 95% CI: 0.006 to 0.112, respectively). Meeting the PA recommendations (60 min/d of MVPA) was significantly associated with higher AST and AST/ALT, which persisted after further adjusting for sedentary time and waist circumference. Sedentary time was not associated with any of the studied liver enzyme levels.Conclusion:Meeting the current PA recommendations of 60 min/d of MVPA is associated with higher levels of AST and AST/ALT regardless of time spent sedentary as well as total and central body fat in European adolescents.

Original languageEnglish
Pages (from-to)798-802
Number of pages5
JournalPediatric Research
Volume75
Issue number6
DOIs
Publication statusPublished - 2014

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Alanine
Exercise
Liver
Enzymes
Accelerometry
Confidence Intervals
Waist Circumference
Aspartic Acid
Adipose Tissue
Serum

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Medicine(all)

Cite this

Ruiz, J. R., Labayen, I., Ortega, F. B., Moreno, L. A., Rodriguez, G., Breidenassel, C., ... Sjöström, M. (2014). Physical activity, sedentary time, and liver enzymes in adolescents: The HELENA study. Pediatric Research, 75(6), 798-802. https://doi.org/10.1038/pr.2014.26

Physical activity, sedentary time, and liver enzymes in adolescents : The HELENA study. / Ruiz, Jonatan R.; Labayen, Idoia; Ortega, Francisco B.; Moreno, Luis A.; Rodriguez, Gerardo; Breidenassel, Christina; Manios, Yannis; Kafatos, Anthony; Molnár, D.; De Henauw, Stephaan; Gottrand, Frederic; Widhalm, Kurt; Castillo, Manuel J.; Sjöström, Michael.

In: Pediatric Research, Vol. 75, No. 6, 2014, p. 798-802.

Research output: Contribution to journalArticle

Ruiz, JR, Labayen, I, Ortega, FB, Moreno, LA, Rodriguez, G, Breidenassel, C, Manios, Y, Kafatos, A, Molnár, D, De Henauw, S, Gottrand, F, Widhalm, K, Castillo, MJ & Sjöström, M 2014, 'Physical activity, sedentary time, and liver enzymes in adolescents: The HELENA study', Pediatric Research, vol. 75, no. 6, pp. 798-802. https://doi.org/10.1038/pr.2014.26
Ruiz JR, Labayen I, Ortega FB, Moreno LA, Rodriguez G, Breidenassel C et al. Physical activity, sedentary time, and liver enzymes in adolescents: The HELENA study. Pediatric Research. 2014;75(6):798-802. https://doi.org/10.1038/pr.2014.26
Ruiz, Jonatan R. ; Labayen, Idoia ; Ortega, Francisco B. ; Moreno, Luis A. ; Rodriguez, Gerardo ; Breidenassel, Christina ; Manios, Yannis ; Kafatos, Anthony ; Molnár, D. ; De Henauw, Stephaan ; Gottrand, Frederic ; Widhalm, Kurt ; Castillo, Manuel J. ; Sjöström, Michael. / Physical activity, sedentary time, and liver enzymes in adolescents : The HELENA study. In: Pediatric Research. 2014 ; Vol. 75, No. 6. pp. 798-802.
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abstract = "Background:To examine the association between physical activity (PA) and liver enzyme levels in adolescents from nine European countries.Methods:The study comprised 718 adolescents (397 girls). PA was measured by accelerometry and expressed as total PA (counts/min), and time (min/d) engaged in moderate to vigorous intensity PA (MVPA). Time spent sedentary was also objectively measured. We measured serum levels of alanine aspartate aminostrasferase (AST), alanine aminostransferase (ALT), and γ-glutamyltrasnferase (GGT), and the AST/ALT ratio was computed.Results:There was an association between MVPA and AST and AST/ALT (age, sex, and center-adjusted β = 0.096, 95{\%} confidence interval (CI): 0.016 to 0.118; and β = 0.090, 95{\%} CI: 0.006 to 0.112, respectively). Meeting the PA recommendations (60 min/d of MVPA) was significantly associated with higher AST and AST/ALT, which persisted after further adjusting for sedentary time and waist circumference. Sedentary time was not associated with any of the studied liver enzyme levels.Conclusion:Meeting the current PA recommendations of 60 min/d of MVPA is associated with higher levels of AST and AST/ALT regardless of time spent sedentary as well as total and central body fat in European adolescents.",
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AU - Ortega, Francisco B.

AU - Moreno, Luis A.

AU - Rodriguez, Gerardo

AU - Breidenassel, Christina

AU - Manios, Yannis

AU - Kafatos, Anthony

AU - Molnár, D.

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AB - Background:To examine the association between physical activity (PA) and liver enzyme levels in adolescents from nine European countries.Methods:The study comprised 718 adolescents (397 girls). PA was measured by accelerometry and expressed as total PA (counts/min), and time (min/d) engaged in moderate to vigorous intensity PA (MVPA). Time spent sedentary was also objectively measured. We measured serum levels of alanine aspartate aminostrasferase (AST), alanine aminostransferase (ALT), and γ-glutamyltrasnferase (GGT), and the AST/ALT ratio was computed.Results:There was an association between MVPA and AST and AST/ALT (age, sex, and center-adjusted β = 0.096, 95% confidence interval (CI): 0.016 to 0.118; and β = 0.090, 95% CI: 0.006 to 0.112, respectively). Meeting the PA recommendations (60 min/d of MVPA) was significantly associated with higher AST and AST/ALT, which persisted after further adjusting for sedentary time and waist circumference. Sedentary time was not associated with any of the studied liver enzyme levels.Conclusion:Meeting the current PA recommendations of 60 min/d of MVPA is associated with higher levels of AST and AST/ALT regardless of time spent sedentary as well as total and central body fat in European adolescents.

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