Physical activity attenuates the negative effect of low birth weight on leptin levels in European adolescents; The HELENA study

I. Labayen, F. B. Ortega, L. A. Moreno, M. Gonzalez-Gross, D. Jimenez-Pavon, D. Martínez-Gómez, C. Breidenassel, A. Marcos, D. Molnar, Y. Manios, M. Plada, A. Kafatos, S. De Henauw, B. Mauro, M. Zaccaria, K. Widhalm, F. Gottrand, M. J. Castillo, M. Sjöström, J. R. Ruiz

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Abstract

We examined whether physical activity (PA) influences the association between birth weight and serum leptin in adolescents. The study comprised a total of 538 adolescents (315 girls), aged 12.5-17.49 years, born at term (≥37 weeks of gestation). We measured serum leptin levels and time engaged in moderate-vigorous PA (MVPA) by accelerometry. There was an interaction effect between birth weight and meeting the PA recommendations (60 min/day MVPA) on leptin levels in girls (P = 0.023) but not in boys (P = 0.809). Birth weight was negatively associated with leptin levels in girls not meeting the PA recommendations (i.e. more than 60 min/day of MVPA) (β = -0.096, P = 0.009), whereas no significant association was observed in those meeting the PA recommendations (β = -0.061, P = 0.433). In conclusion, meeting the PA recommendations may attenuate the negative effect of low birth weight on serum leptin levels in European female adolescents.

Original languageEnglish
Pages (from-to)344-349
Number of pages6
JournalNutrition, Metabolism and Cardiovascular Diseases
Volume23
Issue number4
DOIs
Publication statusPublished - Apr 1 2013

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Keywords

  • Adolescents
  • Birth weight
  • Insulin
  • Leptin
  • Physical activity

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Endocrinology, Diabetes and Metabolism
  • Nutrition and Dietetics
  • Cardiology and Cardiovascular Medicine

Cite this

Labayen, I., Ortega, F. B., Moreno, L. A., Gonzalez-Gross, M., Jimenez-Pavon, D., Martínez-Gómez, D., Breidenassel, C., Marcos, A., Molnar, D., Manios, Y., Plada, M., Kafatos, A., De Henauw, S., Mauro, B., Zaccaria, M., Widhalm, K., Gottrand, F., Castillo, M. J., Sjöström, M., & Ruiz, J. R. (2013). Physical activity attenuates the negative effect of low birth weight on leptin levels in European adolescents; The HELENA study. Nutrition, Metabolism and Cardiovascular Diseases, 23(4), 344-349. https://doi.org/10.1016/j.numecd.2011.12.004