Photopigment coexpression in mammals: Comparative and developmental aspects

Á Lukáts, A. Szabó, P. Röhlich, B. Vígh, A. Szél

Research output: Contribution to journalArticle

62 Citations (Scopus)

Abstract

In mammals, each cone had been thought to contain onlyn one single type of photopigment. It was not until the early 1990s that photopigment coexpression was reported. In the house mouse, the distribution of color cones shows a characteristic division. Whereas in the upper retinal field the ratio of short wave to middle-to-long wave cones falls in the usual range (1:10), in the ventral retinal field M/L-pigment expression is completely missing. In the transitional zone, numerous dual cones are detectable (spatial coexpression). In other species without retinal division, dual cones appear during development, suggesting that M/L-cones develop from S-cones. Dual elements represent a transitory stage in M/L-cone differentiation that disappear with maturation (transitory coexpression). These two phenomena seem to be mutually exclusive in the species studied so far. In the comparative part of this report the retinal cone distribution of eight rodent species is reported. In two species dual cones appear in adult specimens without retinal division, and dual elements either occupy the dorsal peripheral retina, or make up the entire cone population. This is the first observation proving that all cones of a retina are of dual nature. These species are good models for the study of molecular control of opsin expression and renders them suitable sources of dual cones for investigations on the role and neural connections of this peculiar cone type. In the developmental part, the retinal maturation of other species is examined to test the hypothesis of transitory coexpression. In these species S-pigment expression precedes that of the M/L-pigment, but dual cones are either identified in a small number or they are completely missing from the developing retina. These results exclude a common mechanism for M/L-cone maturation: they either transdifferentiate from S-cones or develop independently.

Original languageEnglish
Pages (from-to)551-574
Number of pages24
JournalHistology and Histopathology
Volume20
Issue number2
Publication statusPublished - Apr 2005

Fingerprint

Retinal Cone Photoreceptor Cells
Retina
Mammals
Radio Waves
Opsins
Molecular Models
Rodentia
Color
Observation
Population

Keywords

  • Cone pigment
  • Cones
  • Immunocytochemistry
  • Retina

ASJC Scopus subject areas

  • Anatomy
  • Pathology and Forensic Medicine
  • Histology
  • Cell Biology

Cite this

Photopigment coexpression in mammals : Comparative and developmental aspects. / Lukáts, Á; Szabó, A.; Röhlich, P.; Vígh, B.; Szél, A.

In: Histology and Histopathology, Vol. 20, No. 2, 04.2005, p. 551-574.

Research output: Contribution to journalArticle

@article{c68ce6ff49434f31b46870659daf66c2,
title = "Photopigment coexpression in mammals: Comparative and developmental aspects",
abstract = "In mammals, each cone had been thought to contain onlyn one single type of photopigment. It was not until the early 1990s that photopigment coexpression was reported. In the house mouse, the distribution of color cones shows a characteristic division. Whereas in the upper retinal field the ratio of short wave to middle-to-long wave cones falls in the usual range (1:10), in the ventral retinal field M/L-pigment expression is completely missing. In the transitional zone, numerous dual cones are detectable (spatial coexpression). In other species without retinal division, dual cones appear during development, suggesting that M/L-cones develop from S-cones. Dual elements represent a transitory stage in M/L-cone differentiation that disappear with maturation (transitory coexpression). These two phenomena seem to be mutually exclusive in the species studied so far. In the comparative part of this report the retinal cone distribution of eight rodent species is reported. In two species dual cones appear in adult specimens without retinal division, and dual elements either occupy the dorsal peripheral retina, or make up the entire cone population. This is the first observation proving that all cones of a retina are of dual nature. These species are good models for the study of molecular control of opsin expression and renders them suitable sources of dual cones for investigations on the role and neural connections of this peculiar cone type. In the developmental part, the retinal maturation of other species is examined to test the hypothesis of transitory coexpression. In these species S-pigment expression precedes that of the M/L-pigment, but dual cones are either identified in a small number or they are completely missing from the developing retina. These results exclude a common mechanism for M/L-cone maturation: they either transdifferentiate from S-cones or develop independently.",
keywords = "Cone pigment, Cones, Immunocytochemistry, Retina",
author = "{\'A} Luk{\'a}ts and A. Szab{\'o} and P. R{\"o}hlich and B. V{\'i}gh and A. Sz{\'e}l",
year = "2005",
month = "4",
language = "English",
volume = "20",
pages = "551--574",
journal = "Histology and Histopathology",
issn = "0213-3911",
publisher = "Histology and Histopathology",
number = "2",

}

TY - JOUR

T1 - Photopigment coexpression in mammals

T2 - Comparative and developmental aspects

AU - Lukáts, Á

AU - Szabó, A.

AU - Röhlich, P.

AU - Vígh, B.

AU - Szél, A.

PY - 2005/4

Y1 - 2005/4

N2 - In mammals, each cone had been thought to contain onlyn one single type of photopigment. It was not until the early 1990s that photopigment coexpression was reported. In the house mouse, the distribution of color cones shows a characteristic division. Whereas in the upper retinal field the ratio of short wave to middle-to-long wave cones falls in the usual range (1:10), in the ventral retinal field M/L-pigment expression is completely missing. In the transitional zone, numerous dual cones are detectable (spatial coexpression). In other species without retinal division, dual cones appear during development, suggesting that M/L-cones develop from S-cones. Dual elements represent a transitory stage in M/L-cone differentiation that disappear with maturation (transitory coexpression). These two phenomena seem to be mutually exclusive in the species studied so far. In the comparative part of this report the retinal cone distribution of eight rodent species is reported. In two species dual cones appear in adult specimens without retinal division, and dual elements either occupy the dorsal peripheral retina, or make up the entire cone population. This is the first observation proving that all cones of a retina are of dual nature. These species are good models for the study of molecular control of opsin expression and renders them suitable sources of dual cones for investigations on the role and neural connections of this peculiar cone type. In the developmental part, the retinal maturation of other species is examined to test the hypothesis of transitory coexpression. In these species S-pigment expression precedes that of the M/L-pigment, but dual cones are either identified in a small number or they are completely missing from the developing retina. These results exclude a common mechanism for M/L-cone maturation: they either transdifferentiate from S-cones or develop independently.

AB - In mammals, each cone had been thought to contain onlyn one single type of photopigment. It was not until the early 1990s that photopigment coexpression was reported. In the house mouse, the distribution of color cones shows a characteristic division. Whereas in the upper retinal field the ratio of short wave to middle-to-long wave cones falls in the usual range (1:10), in the ventral retinal field M/L-pigment expression is completely missing. In the transitional zone, numerous dual cones are detectable (spatial coexpression). In other species without retinal division, dual cones appear during development, suggesting that M/L-cones develop from S-cones. Dual elements represent a transitory stage in M/L-cone differentiation that disappear with maturation (transitory coexpression). These two phenomena seem to be mutually exclusive in the species studied so far. In the comparative part of this report the retinal cone distribution of eight rodent species is reported. In two species dual cones appear in adult specimens without retinal division, and dual elements either occupy the dorsal peripheral retina, or make up the entire cone population. This is the first observation proving that all cones of a retina are of dual nature. These species are good models for the study of molecular control of opsin expression and renders them suitable sources of dual cones for investigations on the role and neural connections of this peculiar cone type. In the developmental part, the retinal maturation of other species is examined to test the hypothesis of transitory coexpression. In these species S-pigment expression precedes that of the M/L-pigment, but dual cones are either identified in a small number or they are completely missing from the developing retina. These results exclude a common mechanism for M/L-cone maturation: they either transdifferentiate from S-cones or develop independently.

KW - Cone pigment

KW - Cones

KW - Immunocytochemistry

KW - Retina

UR - http://www.scopus.com/inward/record.url?scp=16344376276&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=16344376276&partnerID=8YFLogxK

M3 - Article

C2 - 15736061

AN - SCOPUS:16344376276

VL - 20

SP - 551

EP - 574

JO - Histology and Histopathology

JF - Histology and Histopathology

SN - 0213-3911

IS - 2

ER -