CRABTREE1 has demonstrated an inhibition of oxygen consumption in several different malignant tissues following the addition of glucose. Many attempts have since been made, especially during recent years, to explain the mechanism of this phenomenon. Certain workers2,3 regard adenine nucleotides, others4,5 inorganic phosphorus, as responsible for the production of the Crabtree effect and postulate a competition between the oxidative and glycolytic systems for one of these substances. Åcs et al.6 have suggested that a location of enzyme systems unique for the cells involved also plays some part in producing the inhibitory effect.
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