Phosphorylation and DNA binding of the octamer binding transcription factor OCT-3

Edward Rosfjord, Beáta Scholtz, Robert Lewis, Angie Rizzino

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Phosphorylation influences DNA binding and transactivator capabilities of multiple transcription factors. In this study, we demonstrate that the POU-domain transcription factor, Oct-3, can be phosphorylated in vivo. In addition, we show that in COS-1 cells Oct-3 is phosphorylated exclusively on serine residues. Lastly, we provide evidence that phosphorylation is not required for Oct-3 binding to DNA and treatment of Oct-3 with calf intestinal alkaline phosphatase does not influence its ability to bind DNA.

Original languageEnglish
Pages (from-to)847-853
Number of pages7
JournalBiochemical and biophysical research communications
Volume212
Issue number3
DOIs
Publication statusPublished - Jul 26 1995

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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