It is now generally accepted that stratum corneum as the uppermost layer of the skin is a biosensor that regulates metabolic responses of the skin to the changes in the environment.1 Variations in environmental humidity affect the rate of the permeability barrier synthesis. The chain of events involved in this response includes (1) detection of a change in skin hydration (e.g., due to increased transepidermal water loss), (2) activation of a variety of enzymes including phospholipase D (PLD), and (3) modulation of the rate of the pro-barrier to barrier lipid transformation.2 In this chain of events, PLD not only controls the rate of lipid transformation, but is also involved in the release of water-soluble metabolites, which function as organic osmolytes3 and at the same time exert their biological protective activity.4,5 These metabolites play an essential role in the maintenance of a balanced skin hydration.
|Title of host publication||Dry Skin and Moisturizers|
|Subtitle of host publication||Chemistry and Function, Second Edition|
|Number of pages||10|
|ISBN (Print)||0849321344, 9780849321344|
|Publication status||Published - Jan 1 2005|
ASJC Scopus subject areas
- Pharmacology, Toxicology and Pharmaceutics(all)