Phosphatidylinositol 4-kinases

old enzymes with emerging functions

A. Balla, Tamas Balla

Research output: Contribution to journalArticle

232 Citations (Scopus)

Abstract

Phosphoinositides account for only a tiny fraction of cellular phospholipids but are extremely important in the regulation of the recruitment and activity of many signaling proteins in cellular membranes. Phosphatidylinositol (PtdIns) 4-kinases generate PtdIns 4-phosphate, the precursor of important regulatory phosphoinositides but also an emerging regulatory molecule in its own right. The four mammalian PtdIns 4-kinases regulate a diverse array of signaling events, as well as vesicular trafficking and lipid transport, but the mechanisms by which their lipid product PtdIns 4-phosphate controls these processes is only beginning to unfold.

Original languageEnglish
Pages (from-to)351-361
Number of pages11
JournalTrends in Cell Biology
Volume16
Issue number7
DOIs
Publication statusPublished - Jul 2006

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1-Phosphatidylinositol 4-Kinase
Phosphatidylinositols
Personnel Selection
Lipids
Enzymes
Phospholipids
Membranes
Proteins
phosphatidylinositol 4-phosphate

ASJC Scopus subject areas

  • Cell Biology

Cite this

Phosphatidylinositol 4-kinases : old enzymes with emerging functions. / Balla, A.; Balla, Tamas.

In: Trends in Cell Biology, Vol. 16, No. 7, 07.2006, p. 351-361.

Research output: Contribution to journalArticle

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