Phosphatidylinositol 4-kinases: old enzymes with emerging functions

Andras Balla, Tamas Balla

Research output: Contribution to journalReview article

236 Citations (Scopus)

Abstract

Phosphoinositides account for only a tiny fraction of cellular phospholipids but are extremely important in the regulation of the recruitment and activity of many signaling proteins in cellular membranes. Phosphatidylinositol (PtdIns) 4-kinases generate PtdIns 4-phosphate, the precursor of important regulatory phosphoinositides but also an emerging regulatory molecule in its own right. The four mammalian PtdIns 4-kinases regulate a diverse array of signaling events, as well as vesicular trafficking and lipid transport, but the mechanisms by which their lipid product PtdIns 4-phosphate controls these processes is only beginning to unfold.

Original languageEnglish
Pages (from-to)351-361
Number of pages11
JournalTrends in Cell Biology
Volume16
Issue number7
DOIs
Publication statusPublished - Jul 1 2006

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ASJC Scopus subject areas

  • Cell Biology

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