Phorbol ester-induced expression and function of the interleukin 2 receptor in human B lymphocytes

I. Andó, D. H. Crawford, M. A. Kissonerghis, M. J. Owen, P. C. Beverley

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

The expression of the interleukin 2 receptor (Tac) on normal B cells and Epstein-Barr virus-transformed lymphoblastoid B cell lines is induced by the tumor promoter 12-O-tetradecanoyl-phorbol-13-acetate (TPA). The receptor on B cells is indistinguishable from that on T cells by serological and biochemical analysis. It is functionally active so that TPA-induced B cells respond to interleukin 2 by increased DNA synthesis. These results suggest that the expression of Tac is not exclusively restricted to T cells and that interleukin 2 may play a role in B cell differentiation.

Original languageEnglish
Pages (from-to)341-344
Number of pages4
JournalEuropean Journal of Immunology
Volume15
Issue number4
DOIs
Publication statusPublished - 1985

Fingerprint

Interleukin-2 Receptors
Phorbol Esters
B-Lymphocytes
Interleukin-2
T-Lymphocytes
Tetradecanoylphorbol Acetate
Human Herpesvirus 4
Carcinogens
Cell Differentiation
Acetates
Cell Line
DNA

ASJC Scopus subject areas

  • Immunology

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Phorbol ester-induced expression and function of the interleukin 2 receptor in human B lymphocytes. / Andó, I.; Crawford, D. H.; Kissonerghis, M. A.; Owen, M. J.; Beverley, P. C.

In: European Journal of Immunology, Vol. 15, No. 4, 1985, p. 341-344.

Research output: Contribution to journalArticle

Andó, I. ; Crawford, D. H. ; Kissonerghis, M. A. ; Owen, M. J. ; Beverley, P. C. / Phorbol ester-induced expression and function of the interleukin 2 receptor in human B lymphocytes. In: European Journal of Immunology. 1985 ; Vol. 15, No. 4. pp. 341-344.
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