Phenoxybenzamine antagonizes somatostatin-induced antiamnesi in rats

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Abstract

The effects of pretreatment with atropine, haloperidol and phenoxybenzamine on somatostatin-induced antiamnesia were investigated. Somatostatin itself blocked electroconvulsive shock (ECS)-induced amnesia. The receptor blockers per se had no influence on the ECS-induced avoidance latency. Atropine and haloperidol did not inhibit somatostatin-induced antiamnesia, whereas phenoxybenzamine blocked it completely. The results suggest that the central noradrenergic system plays an important role in the mediation of the antiamnesic action of somatostatin.

Original languageEnglish
Pages (from-to)325-328
Number of pages4
JournalEuropean Journal of Pharmacology
Volume99
Issue number4
DOIs
Publication statusPublished - Apr 6 1984

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Keywords

  • Amnesia
  • Atropine
  • Haloperidol
  • Phenoxybenzamine
  • Somatostatin

ASJC Scopus subject areas

  • Pharmacology

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