Phenotypic mixing between murine oncoviruses and murine cytomegalovirus

T. J. Schnitzer, E. Gönczöl

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

In vitro interactions between murine cytomegalovirus (MCMV) and murine leukaemia viruses (MuLV), two groups of enveloped viruses capable of causing persistent or latent infections in vivo, were examined for evidence of phenotypic mixing. The growth of MCMV in murine cells productively infected with ecotropic MuLV was shown to result regularly in the production of phenotypically mixed particles having the envelope antigens of MuLV and the genome of MCMV [MCMV(MuLV) pseudotypes]. The identity of such pseudotype particles was confirmed by the use of specific anti-MuLV serum and by the demonstration of restriction due to viral interference of penetration of these particles on MuLV-infected murine cells. This restriction was independent of N- or B-tropism. The production of reverse pseudotypes could not be examined because of the lytic effects of MCMV on the requisite assay cells.

Original languageEnglish
Pages (from-to)691-695
Number of pages5
JournalJournal of General Virology
Volume43
Issue number3
Publication statusPublished - 1979

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Muromegalovirus
Murine Leukemia Viruses
Retroviridae
Viral Interference
Tropism
Genome
Viruses
Antigens
Growth
Infection
Serum

ASJC Scopus subject areas

  • Immunology
  • Virology

Cite this

Phenotypic mixing between murine oncoviruses and murine cytomegalovirus. / Schnitzer, T. J.; Gönczöl, E.

In: Journal of General Virology, Vol. 43, No. 3, 1979, p. 691-695.

Research output: Contribution to journalArticle

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