Phenothiazine-metal co-ordination complexes as antimutagens

Masaru Tanaka, Dona Mucsi, Joseph Molnár, Sue Kidd

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Abstract

Metal co-ordination complexes of phenothiazmes were studied for their mutagenic and antimutagenic effects. Phenothiazmes are the heterocyclic aromatic hydrocarbons in which nitrogen and sulfur are incorporated in the tricyclic system, being known to have antimutagenic activity by shielding DNA-base pairs. Meanwhile inorganic metals have also been known to have antimutagenic effects by increasing the DNA replication fidelity and suppressing the error-prone repair mechanism . Mutagenicity and antimutagenicity of twelve phenothiazine-metal complexes, four phenothiazines (phenothiazine, promethazme, promazine and chlorpromazine) and three inorganic metals (copper, palladium and gold) are examined on Salmonella typhimurium TA98 strain. For antimutagenicity assay a strain-specific, direct-acting mutagen to DNA, 4-nitro-o-phenylenediamine (4-NPD) was applied for chemical induction of mutation. None of the test chemicals were found to be mutagenic All palladium complexes increased their antimutagenicity compared to their parent compounds, chlorpromazine-palladium co-.

Original languageEnglish
Pages (from-to)S116
JournalMedical Microbiology Letters
Volume5
Issue numberSUPPL. 1
Publication statusPublished - Dec 1 1996

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ASJC Scopus subject areas

  • Microbiology (medical)

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