Phenolic composition, antioxidant and antinociceptive activities of Syringa vulgaris L. bark and leaf extracts

Erzsébet Varga, Csenge Barabás, Anita Tóth, Imre Boldizsár, Béla Noszál, Gergő Tóth

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Metabolite profile, antioxidant and antinociceptive activities of Syringa vulgaris bark and leaf methanolic extracts were investigated. By means of HPLC-DAD-ESI-TOF and HPLC-DAD-ESI-MS/MS, a total of 33 phenolics were identified, including 15 secoiridoids, 6 phenylpropanoids, 3 flavonoids, 3 lignans and 6 low molecular weight phenols. Validated quantitative analysis show that syringin (2.52%) and rutin (1.13%) are the main phenolic compounds in bark and leaf, respectively. Notable radical scavenging and antinociceptive activities of the bark and leaf extracts were confirmed by in vitro DPPH and ABTS●+ assays and by in vivo hot-plate method in mice, respectively. Our results could lay the scientific basic of future clinical perspectives of lilac bark and leaf.

Original languageEnglish
Pages (from-to)1664-1669
Number of pages6
JournalNatural Product Research
Volume33
Issue number11
DOIs
Publication statusPublished - Jun 3 2019

Keywords

  • Phenolic profiling
  • Syringa vulgaris
  • antinociceptive activity
  • antioxidant activity
  • oleuropein

ASJC Scopus subject areas

  • Analytical Chemistry
  • Biochemistry
  • Plant Science
  • Organic Chemistry

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