Phasic relationship between the activity of basal forebrain neurons and cortical EEG in urethane-anesthetized rat

L. Détári, Douglas D. Rasmusson, Kazue Semba

Research output: Contribution to journalArticle

41 Citations (Scopus)

Abstract

Previous studies have shown that a large number of neurons in the basal forebrain have higher firing rates when the cortical electroencephalogram (EEG) is characterized by low-voltage fast activity compared to states characterized by slow waves. A smaller number of cells with increased discharge rates during slow waves have also been observed. This putative ascending effect is thought to be tonic, but no attempt has been made to analyze a closer temporal correlation between the activity of basal forebrain neurons and the cortical EEG. Recordings were made from single units in the basal forebrain concurrently with the cortical EEG in urethane-anesthetized rats. A total of 52 neurons consistently showed higher firing during low- voltage fast activity (F-cells), whereas 14 neurons were consistently more active during cortical slow waves (S-cells). In most of the F- (90%) and S- cells (86%) the change in firing rate occurred prior to the change in the EEG. The average delay was 300-400 ms. At a deep level of anesthesia, the EEG was characterized by an alternation of flat periods and large waves. Most F- cells became active near the start of the first large wave, which is known to correspond to the onset of depolarization of cortical pyramidal neurons. In contrast, most S-cells were less active during the large waves. These data show that the activity of basal forebrain neurons is phasically correlated with the EEG in addition to the tonic correlation that has been demonstrated previously. Both types of basal forebrain neurons change their firing rate prior to the change in cortical EEG, suggesting that the basal forebrain neurons may have a regulatory influence on the EEG.

Original languageEnglish
Pages (from-to)112-121
Number of pages10
JournalBrain Research
Volume759
Issue number1
DOIs
Publication statusPublished - Jun 6 1997

Fingerprint

Urethane
Electroencephalography
Neurons
Basal Forebrain
Pyramidal Cells
Anesthesia
Cell Count

Keywords

  • Basal forebrain
  • Cortical arousal
  • Electroencephalogram
  • Low voltage fast activity
  • Slow wave
  • Unit recording
  • Urethane-anesthetized rat

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Phasic relationship between the activity of basal forebrain neurons and cortical EEG in urethane-anesthetized rat. / Détári, L.; Rasmusson, Douglas D.; Semba, Kazue.

In: Brain Research, Vol. 759, No. 1, 06.06.1997, p. 112-121.

Research output: Contribution to journalArticle

@article{4345a2d496ce4f0d819c4a904d8bd712,
title = "Phasic relationship between the activity of basal forebrain neurons and cortical EEG in urethane-anesthetized rat",
abstract = "Previous studies have shown that a large number of neurons in the basal forebrain have higher firing rates when the cortical electroencephalogram (EEG) is characterized by low-voltage fast activity compared to states characterized by slow waves. A smaller number of cells with increased discharge rates during slow waves have also been observed. This putative ascending effect is thought to be tonic, but no attempt has been made to analyze a closer temporal correlation between the activity of basal forebrain neurons and the cortical EEG. Recordings were made from single units in the basal forebrain concurrently with the cortical EEG in urethane-anesthetized rats. A total of 52 neurons consistently showed higher firing during low- voltage fast activity (F-cells), whereas 14 neurons were consistently more active during cortical slow waves (S-cells). In most of the F- (90{\%}) and S- cells (86{\%}) the change in firing rate occurred prior to the change in the EEG. The average delay was 300-400 ms. At a deep level of anesthesia, the EEG was characterized by an alternation of flat periods and large waves. Most F- cells became active near the start of the first large wave, which is known to correspond to the onset of depolarization of cortical pyramidal neurons. In contrast, most S-cells were less active during the large waves. These data show that the activity of basal forebrain neurons is phasically correlated with the EEG in addition to the tonic correlation that has been demonstrated previously. Both types of basal forebrain neurons change their firing rate prior to the change in cortical EEG, suggesting that the basal forebrain neurons may have a regulatory influence on the EEG.",
keywords = "Basal forebrain, Cortical arousal, Electroencephalogram, Low voltage fast activity, Slow wave, Unit recording, Urethane-anesthetized rat",
author = "L. D{\'e}t{\'a}ri and Rasmusson, {Douglas D.} and Kazue Semba",
year = "1997",
month = "6",
day = "6",
doi = "10.1016/S0006-8993(97)00252-7",
language = "English",
volume = "759",
pages = "112--121",
journal = "Brain Research",
issn = "0006-8993",
publisher = "Elsevier",
number = "1",

}

TY - JOUR

T1 - Phasic relationship between the activity of basal forebrain neurons and cortical EEG in urethane-anesthetized rat

AU - Détári, L.

AU - Rasmusson, Douglas D.

AU - Semba, Kazue

PY - 1997/6/6

Y1 - 1997/6/6

N2 - Previous studies have shown that a large number of neurons in the basal forebrain have higher firing rates when the cortical electroencephalogram (EEG) is characterized by low-voltage fast activity compared to states characterized by slow waves. A smaller number of cells with increased discharge rates during slow waves have also been observed. This putative ascending effect is thought to be tonic, but no attempt has been made to analyze a closer temporal correlation between the activity of basal forebrain neurons and the cortical EEG. Recordings were made from single units in the basal forebrain concurrently with the cortical EEG in urethane-anesthetized rats. A total of 52 neurons consistently showed higher firing during low- voltage fast activity (F-cells), whereas 14 neurons were consistently more active during cortical slow waves (S-cells). In most of the F- (90%) and S- cells (86%) the change in firing rate occurred prior to the change in the EEG. The average delay was 300-400 ms. At a deep level of anesthesia, the EEG was characterized by an alternation of flat periods and large waves. Most F- cells became active near the start of the first large wave, which is known to correspond to the onset of depolarization of cortical pyramidal neurons. In contrast, most S-cells were less active during the large waves. These data show that the activity of basal forebrain neurons is phasically correlated with the EEG in addition to the tonic correlation that has been demonstrated previously. Both types of basal forebrain neurons change their firing rate prior to the change in cortical EEG, suggesting that the basal forebrain neurons may have a regulatory influence on the EEG.

AB - Previous studies have shown that a large number of neurons in the basal forebrain have higher firing rates when the cortical electroencephalogram (EEG) is characterized by low-voltage fast activity compared to states characterized by slow waves. A smaller number of cells with increased discharge rates during slow waves have also been observed. This putative ascending effect is thought to be tonic, but no attempt has been made to analyze a closer temporal correlation between the activity of basal forebrain neurons and the cortical EEG. Recordings were made from single units in the basal forebrain concurrently with the cortical EEG in urethane-anesthetized rats. A total of 52 neurons consistently showed higher firing during low- voltage fast activity (F-cells), whereas 14 neurons were consistently more active during cortical slow waves (S-cells). In most of the F- (90%) and S- cells (86%) the change in firing rate occurred prior to the change in the EEG. The average delay was 300-400 ms. At a deep level of anesthesia, the EEG was characterized by an alternation of flat periods and large waves. Most F- cells became active near the start of the first large wave, which is known to correspond to the onset of depolarization of cortical pyramidal neurons. In contrast, most S-cells were less active during the large waves. These data show that the activity of basal forebrain neurons is phasically correlated with the EEG in addition to the tonic correlation that has been demonstrated previously. Both types of basal forebrain neurons change their firing rate prior to the change in cortical EEG, suggesting that the basal forebrain neurons may have a regulatory influence on the EEG.

KW - Basal forebrain

KW - Cortical arousal

KW - Electroencephalogram

KW - Low voltage fast activity

KW - Slow wave

KW - Unit recording

KW - Urethane-anesthetized rat

UR - http://www.scopus.com/inward/record.url?scp=0342437558&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0342437558&partnerID=8YFLogxK

U2 - 10.1016/S0006-8993(97)00252-7

DO - 10.1016/S0006-8993(97)00252-7

M3 - Article

VL - 759

SP - 112

EP - 121

JO - Brain Research

JF - Brain Research

SN - 0006-8993

IS - 1

ER -