Pharmacology of the capsaicin receptor, transient receptor potential vanilloid type-1 ion channel

I. Nagy, Dominic Friston, João Sousa Valente, Jose Vicente Torres Perez, Anna P. Andreou

Research output: Chapter in Book/Report/Conference proceedingChapter

32 Citations (Scopus)

Abstract

The capsaicin receptor, transient receptor potential vanilloid type 1 ion channel (TRPV1), has been identified as a polymodal transducer molecule on a sub-set of primary sensory neurons which responds to various stimuli including noxious heat (>~42 °C), protons and vanilloids such as capsaicin, the hot ingredient of chilli peppers. Subsequently, TRPV1 has been found indispensable for the development of burning pain and reflex hyperactivity associated with inflammation of peripheral tissues and viscera, respectively. Therefore, TRPV1 is regarded as a major target for the development of novel agents for the control of pain and visceral hyperreflexia in inflammatory conditions. Initial efforts to introduce agents acting on TRPV1 into clinics have been hampered by unexpected side-effects due to wider than expected expression in various tissues, as well as by the complex pharmacology, of TRPV1. However, it is believed that better understanding of the pharmacological properties of TRPV1 and specific targeting of tissues may eventually lead to the development of clinically useful agents. In order to assist better understanding of TRPV1 pharmacology, here we are giving a comprehensive account on the activation and inactivation mechanisms and the structure-function relationship of TRPV1.

Original languageEnglish
Title of host publicationProgress in Drug Research
PublisherBirkhauser Verlag AG
Pages39-76
Number of pages38
Volume68
ISBN (Print)9783034808279
DOIs
Publication statusPublished - 2014

Publication series

NameProgress in Drug Research
Volume68
ISSN (Print)0071786X

Fingerprint

TRPV Cation Channels
Ion Channels
Pharmacology
Pain
Abnormal Reflexes
Capsicum
Viscera
vanilloid receptor subtype 1
Capsaicin
Sensory Receptor Cells
Transducers
Reflex
Protons
Hot Temperature
Inflammation

ASJC Scopus subject areas

  • Pharmacology, Toxicology and Pharmaceutics(all)
  • Molecular Medicine

Cite this

Nagy, I., Friston, D., Valente, J. S., Perez, J. V. T., & Andreou, A. P. (2014). Pharmacology of the capsaicin receptor, transient receptor potential vanilloid type-1 ion channel. In Progress in Drug Research (Vol. 68, pp. 39-76). (Progress in Drug Research; Vol. 68). Birkhauser Verlag AG. https://doi.org/10.1007/978-3-0348-0828-6-2

Pharmacology of the capsaicin receptor, transient receptor potential vanilloid type-1 ion channel. / Nagy, I.; Friston, Dominic; Valente, João Sousa; Perez, Jose Vicente Torres; Andreou, Anna P.

Progress in Drug Research. Vol. 68 Birkhauser Verlag AG, 2014. p. 39-76 (Progress in Drug Research; Vol. 68).

Research output: Chapter in Book/Report/Conference proceedingChapter

Nagy, I, Friston, D, Valente, JS, Perez, JVT & Andreou, AP 2014, Pharmacology of the capsaicin receptor, transient receptor potential vanilloid type-1 ion channel. in Progress in Drug Research. vol. 68, Progress in Drug Research, vol. 68, Birkhauser Verlag AG, pp. 39-76. https://doi.org/10.1007/978-3-0348-0828-6-2
Nagy I, Friston D, Valente JS, Perez JVT, Andreou AP. Pharmacology of the capsaicin receptor, transient receptor potential vanilloid type-1 ion channel. In Progress in Drug Research. Vol. 68. Birkhauser Verlag AG. 2014. p. 39-76. (Progress in Drug Research). https://doi.org/10.1007/978-3-0348-0828-6-2
Nagy, I. ; Friston, Dominic ; Valente, João Sousa ; Perez, Jose Vicente Torres ; Andreou, Anna P. / Pharmacology of the capsaicin receptor, transient receptor potential vanilloid type-1 ion channel. Progress in Drug Research. Vol. 68 Birkhauser Verlag AG, 2014. pp. 39-76 (Progress in Drug Research).
@inbook{beaa22172509421d8c23150f22b1bb19,
title = "Pharmacology of the capsaicin receptor, transient receptor potential vanilloid type-1 ion channel",
abstract = "The capsaicin receptor, transient receptor potential vanilloid type 1 ion channel (TRPV1), has been identified as a polymodal transducer molecule on a sub-set of primary sensory neurons which responds to various stimuli including noxious heat (>~42 °C), protons and vanilloids such as capsaicin, the hot ingredient of chilli peppers. Subsequently, TRPV1 has been found indispensable for the development of burning pain and reflex hyperactivity associated with inflammation of peripheral tissues and viscera, respectively. Therefore, TRPV1 is regarded as a major target for the development of novel agents for the control of pain and visceral hyperreflexia in inflammatory conditions. Initial efforts to introduce agents acting on TRPV1 into clinics have been hampered by unexpected side-effects due to wider than expected expression in various tissues, as well as by the complex pharmacology, of TRPV1. However, it is believed that better understanding of the pharmacological properties of TRPV1 and specific targeting of tissues may eventually lead to the development of clinically useful agents. In order to assist better understanding of TRPV1 pharmacology, here we are giving a comprehensive account on the activation and inactivation mechanisms and the structure-function relationship of TRPV1.",
author = "I. Nagy and Dominic Friston and Valente, {Jo{\~a}o Sousa} and Perez, {Jose Vicente Torres} and Andreou, {Anna P.}",
year = "2014",
doi = "10.1007/978-3-0348-0828-6-2",
language = "English",
isbn = "9783034808279",
volume = "68",
series = "Progress in Drug Research",
publisher = "Birkhauser Verlag AG",
pages = "39--76",
booktitle = "Progress in Drug Research",

}

TY - CHAP

T1 - Pharmacology of the capsaicin receptor, transient receptor potential vanilloid type-1 ion channel

AU - Nagy, I.

AU - Friston, Dominic

AU - Valente, João Sousa

AU - Perez, Jose Vicente Torres

AU - Andreou, Anna P.

PY - 2014

Y1 - 2014

N2 - The capsaicin receptor, transient receptor potential vanilloid type 1 ion channel (TRPV1), has been identified as a polymodal transducer molecule on a sub-set of primary sensory neurons which responds to various stimuli including noxious heat (>~42 °C), protons and vanilloids such as capsaicin, the hot ingredient of chilli peppers. Subsequently, TRPV1 has been found indispensable for the development of burning pain and reflex hyperactivity associated with inflammation of peripheral tissues and viscera, respectively. Therefore, TRPV1 is regarded as a major target for the development of novel agents for the control of pain and visceral hyperreflexia in inflammatory conditions. Initial efforts to introduce agents acting on TRPV1 into clinics have been hampered by unexpected side-effects due to wider than expected expression in various tissues, as well as by the complex pharmacology, of TRPV1. However, it is believed that better understanding of the pharmacological properties of TRPV1 and specific targeting of tissues may eventually lead to the development of clinically useful agents. In order to assist better understanding of TRPV1 pharmacology, here we are giving a comprehensive account on the activation and inactivation mechanisms and the structure-function relationship of TRPV1.

AB - The capsaicin receptor, transient receptor potential vanilloid type 1 ion channel (TRPV1), has been identified as a polymodal transducer molecule on a sub-set of primary sensory neurons which responds to various stimuli including noxious heat (>~42 °C), protons and vanilloids such as capsaicin, the hot ingredient of chilli peppers. Subsequently, TRPV1 has been found indispensable for the development of burning pain and reflex hyperactivity associated with inflammation of peripheral tissues and viscera, respectively. Therefore, TRPV1 is regarded as a major target for the development of novel agents for the control of pain and visceral hyperreflexia in inflammatory conditions. Initial efforts to introduce agents acting on TRPV1 into clinics have been hampered by unexpected side-effects due to wider than expected expression in various tissues, as well as by the complex pharmacology, of TRPV1. However, it is believed that better understanding of the pharmacological properties of TRPV1 and specific targeting of tissues may eventually lead to the development of clinically useful agents. In order to assist better understanding of TRPV1 pharmacology, here we are giving a comprehensive account on the activation and inactivation mechanisms and the structure-function relationship of TRPV1.

UR - http://www.scopus.com/inward/record.url?scp=84901194844&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84901194844&partnerID=8YFLogxK

U2 - 10.1007/978-3-0348-0828-6-2

DO - 10.1007/978-3-0348-0828-6-2

M3 - Chapter

C2 - 24941664

AN - SCOPUS:84901194844

SN - 9783034808279

VL - 68

T3 - Progress in Drug Research

SP - 39

EP - 76

BT - Progress in Drug Research

PB - Birkhauser Verlag AG

ER -