Pharmacology of a new orally active antiallergic: Pyrido[1,2-a]pyrimidine, ucb L140 (CHINOIN 1045) in rats

C. de Vos, F. Dessy, I. Hermecz, Z. Meszaros, T. Breining

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Abstract

ucb L140 (CHINOIN 1045) has been tested in various rat anaphylaxis systems. In models of passive cutaneous anaphylaxis (PCA), passive peritoneal anaphylaxis (PPA) and anaphylactic bronchospasms, ucb L140 appears to be more potent than sodium cromoglycate (DSCG). Upon oral administration, ucb L140 exhibits a marked inhibition of these anaphlactic reaction. Sensitized rat mast cells in vitro display a decreased Nippostrongylus-induced histamine release when treated with a concentration of ucb L140 three times smaller than DSCG. In PCA testing after intravenous administration of ucb L140 a cross-tachyphylaxis with DSCG was observed. These results suggest that the action of ucb L140 is similar to that of DSCG in inhibiting the release of allergic mediators from mast cells and therefore may present antiallergic activity.

Original languageEnglish
Pages (from-to)362-368
Number of pages7
JournalInternational Archives of Allergy and Applied Immunology
Volume67
Issue number4
Publication statusPublished - Jun 11 1982

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ASJC Scopus subject areas

  • Immunology and Allergy

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