Pharmacologically induced stereotyped locomotory movements in the pelecypod mollusc, Anodonta Cygnea

D. A. Sakharov, L. Hiripi, J. Salánki

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

1. Bathing freshwater mussels in water containing ergotamine or methylergometrine induced rhythmic coordinated movements of the foot and shell maintained in a stereotyped form for hours. The effect was weak at 10-9mol/1, moderate to strong at 1-4 × 10-8 mol/1, and irreversible to lethal at 5-8 × 10-8 mol/1. 2. Bathing mussels in serotonin (10-20 μmol/1) induced similar movements. They closely correspond to the well-known digging cycles exhibited by pelecypod molluscs during burrowing locomotion. 3. The serotonin content of central ganglia was not changed significantly in mussels exhibiting the ergot-induced locomotory movements. Ergotamine, up to 10-5-10-6 mol/1, did not affect the spontaneous and evoked liberation of serotonin, as well as the serotonin uptake. There is thus little indication of any direct influence of ergots on serotonergic mechanisms.

Original languageEnglish
Pages (from-to)343-347
Number of pages5
JournalComparative Biochemistry and Physiology. Part C, Comparative
Volume92
Issue number2
DOIs
Publication statusPublished - 1989

ASJC Scopus subject areas

  • Immunology
  • Pharmacology

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