Pharmacological Therapy in Parkinson's Disease: Focus on Neuroprotection

Zsigmond Tamas Kincses, Laszlo Vecsei

Research output: Contribution to journalReview article

31 Citations (Scopus)

Abstract

Although the number of available therapeutic approaches in Parkinson's disease (PD) is steadily increasing the search for effective neuroprotective agent is continuing. Such research is directed at influencing the key steps in the pathomechanism: the mitochondrial dysfunction, the oxidative stress, the neuroinflammatory processes and the final common apoptotic pathway. Earlier-developed symptomatic therapies were implicated to be neuroprotective, and promising novel disease modifying approaches were brought into the focus of interest. The current review presents a survey of our current knowledge relating to the pathomechanism of PD and discusses the putative neuroprotective therapy.

Original languageEnglish
Pages (from-to)345-367
Number of pages23
JournalCNS Neuroscience and Therapeutics
Volume17
Issue number5
DOIs
Publication statusPublished - Oct 2011

Keywords

  • Dopamine agonists
  • Genetics
  • Kynurenine
  • L-dopa
  • Mitochondrion
  • Parkinson's disease

ASJC Scopus subject areas

  • Pharmacology
  • Psychiatry and Mental health
  • Physiology (medical)
  • Pharmacology (medical)

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