Pharmacological profile of gamma-aminobutyric acid (GABA) receptors of identified central neurones from Helix Aspersa

Agnes Vehovszky, Anita J. Bokisch, Povl Krogsgaard-Larsen, Robert J. Walker

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

1. Intracellular recordings were made from identified Helix neurones which were either excited, "D" response or inhibited, "H" response by GABA. The pharmacological profile in terms of agonists and antagonists was investigated. 2. Baclofen had no effect on these cells indicating the absence of a GABA-B receptor. Both "H" and "D" GABA receptors were activated by muscimol and antagonised by plcrotoxin. Bicuculline only antagonised the "H" response. Very few GABA agonists were active on the "H" receptor while a number including homomuscimol, THIP and isoguvacine were of a similar order of potency to GABA on the "D" receptor. 3. SR 95531 antagonised the effect of GABA on both "H" and "D" responses while pitrazepin was inactive. The GABA agonist, P-4-S, was an antagonist at the "D" receptor but did not appear to interact at the "H" site. 4. It is concluded that the "D" receptor has some similarity with the mammalian GABA-A receptor but further studies are required to elucidate this point.

Original languageEnglish
Pages (from-to)391-399
Number of pages9
JournalComparative Biochemistry and Physiology. Part C, Comparative
Volume92
Issue number2
DOIs
Publication statusPublished - 1989

ASJC Scopus subject areas

  • Immunology
  • Pharmacology

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