Pharmacological modulation of ion channels and transporters

Ursula Ravens, Erich Wettwer, Ottá Hála

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Ion channels and transporter proteins are prerequisites for formation and conduction of cardiac electrical impulses. Acting in concert, these proteins maintain cellular Na+ and Ca2+ homeostasis. Since intracellular Ca2+ concentration determines contractile activation, we expect the majority of agents that modulate activity of ion channels and transporters not only to influence cellular action potentials but also contractile force. Drugs which block ion channels usually possess antiarrhythmic properties, those inhibiting the Na+ pump have predominantly inotropic effects and those affecting Na+,Ca2+- or Na+,H+-exchanger protect against ischaemic cell damage. However, irrespective of their primary indication, all compounds targeted against ion channels and transporter proteins possess potential proarrhythmic activity.

Original languageEnglish
Pages (from-to)575-582
Number of pages8
JournalCell Calcium
Volume35
Issue number6
DOIs
Publication statusPublished - Jun 2004

Keywords

  • Antiarrhythmic drugs
  • Cardiac myocytes
  • Inotropic drugs
  • Ion channels
  • Ion transporters

ASJC Scopus subject areas

  • Physiology
  • Molecular Biology
  • Cell Biology

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