Pharmacological modification of the dispersion of repolarization in the heart: Importance of the M cells

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3 Citations (Scopus)

Abstract

Several in vitro and in vivo investigations have provided data supporting the existence of M cells in the deep subepicardial layers of the ventricles in a number of species. Characterized by unique electrophysiological and pharmacological features, this population of cells is regarded to have a significant role in creating dispersion of repolarization in the ventricular wall and thus contribute importantly to arrhythmogenesis, in particular to intramural reentry and triggered activity. Focusing on M cells, the authors summarize recent findings and concepts concerning the pharmacological heterogeneity of different cell and tissue types found within the ventricles and explore how these differences may contribute to electrocardiographic manifestations. On the basis of literarary data and of their own results they conclude that studying the electrical and pharmacological inhomogeneity within the ventricular wall may provide a better understanding of the pathophysiological processes that give rise to cardiac rhythm disturbances and the mechanisms by which antiarrhythmic agents act to suppress and in some cases aggravate arrhythmias.

Original languageEnglish
Pages (from-to)491-505
Number of pages15
JournalCardiovascular Drugs and Therapy
Volume13
Issue number6
DOIs
Publication statusPublished - Dec 1 1999

Keywords

  • Action potential duration
  • Arrhythmia
  • Dispersion of repolarization
  • M cells
  • Pharmacology
  • Rate dependence

ASJC Scopus subject areas

  • Pharmacology
  • Cardiology and Cardiovascular Medicine
  • Pharmacology (medical)

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