Pharmacological inhibition of brain carbonic anhydrase protects against 4-aminopyridine seizures

A. Mihály, K. Bencsik, A. Nogradi

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

The effects of the inhibition of carbonic anhydrase on the manifestation of tonic-clonic seizures were investigated in freely-moving rats. 4-Aminopyridine, a specific blocker of the neuronal K+ channels was used to produce generalized convulsions. After pretreatment of adult male rats with 20 or 40 mg/kg acetazolamide, 3, 5, 7 or 9 mg/kg 4-aminopyridine was injected intraperitoneally and the latencies of the symptoms were measured. Pharmacological inhibition of brain carbonic anhydrase significantly increased the latency of onset of seizures. Bolus administration of acetazolamide decreased the incidence of generalized convulsions and protected against status epilepticus. Chronic acetazolamide treatment for 2 days affected only the generalized convulsions. The results suggested that alterations of the extracellular and intracellular pH by acetazolamide decreased the efficacy of synaptic transmission in several areas of the brain. The possible effects of HCO3- ions on the sensitivity of synaptic and nonsynaptic neuronal receptors are discussed.

Original languageEnglish
Pages (from-to)99-108
Number of pages10
JournalActa Physiologica Hungarica
Volume82
Issue number2
Publication statusPublished - 1994

Fingerprint

4-Aminopyridine
Carbonic Anhydrases
Acetazolamide
Seizures
Pharmacology
Brain
Status Epilepticus
Synaptic Transmission
Ions
Incidence

Keywords

  • 4-aminopyridine
  • acetazolamide
  • carbonic anhydrase
  • rat
  • seizure

ASJC Scopus subject areas

  • Physiology

Cite this

Pharmacological inhibition of brain carbonic anhydrase protects against 4-aminopyridine seizures. / Mihály, A.; Bencsik, K.; Nogradi, A.

In: Acta Physiologica Hungarica, Vol. 82, No. 2, 1994, p. 99-108.

Research output: Contribution to journalArticle

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