Pharmacological evidence for the presence of cholecystokinin-containing neurones in the mesenteric nerves supplying the guinea-pig ileum

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Abstract

In guanethidine-treated, capsaicin-desensitized segments of guinea-pig isolated ileum electrical stimulation of mesenteric nerves resulted in contractions reaching 10 to 30% of the maximal longitudinal spasm. These responses were abolished by tetrodotoxin or atropine, and were reduced by half by the selective cholecystokinin antagonist lorglumide. It is concluded that neuronal processes whose endings release cholecystokinin-like material within the gut wall run in the mesenteric nerves and contribute to the capsaicin-resistant contractile response by releasing endogenous acetylcholine.

Original languageEnglish
Pages (from-to)643-645
Number of pages3
JournalNeuropharmacology
Volume28
Issue number6
DOIs
Publication statusPublished - 1989

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Capsaicin
Cholecystokinin
Ileum
Guinea Pigs
Pharmacology
Neurons
Guanethidine
Tetrodotoxin
Spasm
Atropine
Electric Stimulation
Acetylcholine
lorglumide

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Drug Discovery
  • Pharmacology

Cite this

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title = "Pharmacological evidence for the presence of cholecystokinin-containing neurones in the mesenteric nerves supplying the guinea-pig ileum",
abstract = "In guanethidine-treated, capsaicin-desensitized segments of guinea-pig isolated ileum electrical stimulation of mesenteric nerves resulted in contractions reaching 10 to 30{\%} of the maximal longitudinal spasm. These responses were abolished by tetrodotoxin or atropine, and were reduced by half by the selective cholecystokinin antagonist lorglumide. It is concluded that neuronal processes whose endings release cholecystokinin-like material within the gut wall run in the mesenteric nerves and contribute to the capsaicin-resistant contractile response by releasing endogenous acetylcholine.",
author = "L. Barth{\'o}",
year = "1989",
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journal = "Neuropharmacology",
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AU - Barthó, L.

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N2 - In guanethidine-treated, capsaicin-desensitized segments of guinea-pig isolated ileum electrical stimulation of mesenteric nerves resulted in contractions reaching 10 to 30% of the maximal longitudinal spasm. These responses were abolished by tetrodotoxin or atropine, and were reduced by half by the selective cholecystokinin antagonist lorglumide. It is concluded that neuronal processes whose endings release cholecystokinin-like material within the gut wall run in the mesenteric nerves and contribute to the capsaicin-resistant contractile response by releasing endogenous acetylcholine.

AB - In guanethidine-treated, capsaicin-desensitized segments of guinea-pig isolated ileum electrical stimulation of mesenteric nerves resulted in contractions reaching 10 to 30% of the maximal longitudinal spasm. These responses were abolished by tetrodotoxin or atropine, and were reduced by half by the selective cholecystokinin antagonist lorglumide. It is concluded that neuronal processes whose endings release cholecystokinin-like material within the gut wall run in the mesenteric nerves and contribute to the capsaicin-resistant contractile response by releasing endogenous acetylcholine.

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