Pharmacological evaluation of the stress-induced social avoidance model of anxiety

Cs Leveleki, N. Sziray, G. Levay, B. Barsvári, K. Soproni, É Mikics, J. Haller

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21 Citations (Scopus)

Abstract

We have shown earlier that mild electric shocks induce a lasting social avoidance in male rats. Here we investigated whether shock-induced social avoidance can be developed into a laboratory model of stress-induced anxiety. The putative new model would assess sub-chronic, stress-induced anxiety (as opposed to tests based on natural fear) in a heterologous context (as opposed to classical fear conditioning). A single exposure to mild electric shocks induced a robust social avoidance that lasted more than 5 days. Low doses of chlordiazepoxide (0.5, 1 mg/kg), diazepam (0.5, 1, 5 mg/kg), buspirone (0.3, 1 mg/kg), and fluoxetine (1, 3, 5 mg/kg) abolished this effect, whereas the anxiogenic compound m-chlorophenylpiperazine (0.5-3 mg/kg) induced social avoidance in unshocked rats. These effects were produced at doses that did not affect locomotion in the open field. Haloperidol (0.05, 0.1, 1, 5 mg/kg) influenced social avoidance at sedative doses only. The sensitivity of the model to anxiolytic agents was compromised at high (sedating) doses. Taken conjointly, these data show that shock-induced social avoidance can be used to assess the anxiolytic potential of compounds. In addition to predictive validity, the model appears to show construct and face validity as well: stress is among the etiological factors of, whereas social avoidance simulates the social deficits seen in, a variety of anxiety disorders. The model may be used to study the effects of anxiolytics on sub-chronic states of stress-induced anxiety.

Original languageEnglish
Pages (from-to)153-160
Number of pages8
JournalBrain Research Bulletin
Volume69
Issue number2
DOIs
Publication statusPublished - Mar 31 2006

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Keywords

  • Anxiety
  • Benzodiazepines
  • Buspirone
  • Fluoxetine
  • Stress
  • m- Chlorophenylpiperazine

ASJC Scopus subject areas

  • Neuroscience(all)

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