Pharmacological analysis of nerves supplying the oesophagus

V. Halmai, A. Lotfi Tabrizi, O. Horvath, L. Barthó

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Morphological studies indicate that cholinergic, peptidergic and "nitrergic" (nitric oxide releasing) nerves supply the oesophageal muscle. In the present in vitro study, intramural nerves of guineapig and human oesophagus were activated by means of the ganglion stimulating drug nicotine and electrical field stimulation (EFS) in organ bath experiments. In general, stimulation-induced primary contractions were diminished by atropine, while non-adrenergic, non-cholinergic (NANC) relaxations and after-contractions were inhibited by the NO-synthase inhibitor NG-nitro-L-arginine (L-NNA). Thus we obtained pharmacological evidence for cholinergic muscarinic, as well as nitric oxide mediated mechanisms in the functional innervation of the oesophageal muscle.

Original languageEnglish
Pages (from-to)291-292
Number of pages2
JournalActa Physiologica Hungarica
Volume84
Issue number3
Publication statusPublished - 1996

Fingerprint

Cholinergic Agents
Esophagus
Pharmacology
Nitric Oxide
Muscles
Nitroarginine
Nicotine
Baths
Atropine
Nitric Oxide Synthase
Ganglia
Electric Stimulation
Pharmaceutical Preparations
In Vitro Techniques

Keywords

  • Cholinergic nerves
  • Guinea-pig oesophagus
  • Human oesophagus
  • Nitrergic innervation

ASJC Scopus subject areas

  • Physiology

Cite this

Pharmacological analysis of nerves supplying the oesophagus. / Halmai, V.; Lotfi Tabrizi, A.; Horvath, O.; Barthó, L.

In: Acta Physiologica Hungarica, Vol. 84, No. 3, 1996, p. 291-292.

Research output: Contribution to journalArticle

Halmai, V. ; Lotfi Tabrizi, A. ; Horvath, O. ; Barthó, L. / Pharmacological analysis of nerves supplying the oesophagus. In: Acta Physiologica Hungarica. 1996 ; Vol. 84, No. 3. pp. 291-292.
@article{5a054b2fc03f475e9b35aa90a5a3c8bc,
title = "Pharmacological analysis of nerves supplying the oesophagus",
abstract = "Morphological studies indicate that cholinergic, peptidergic and {"}nitrergic{"} (nitric oxide releasing) nerves supply the oesophageal muscle. In the present in vitro study, intramural nerves of guineapig and human oesophagus were activated by means of the ganglion stimulating drug nicotine and electrical field stimulation (EFS) in organ bath experiments. In general, stimulation-induced primary contractions were diminished by atropine, while non-adrenergic, non-cholinergic (NANC) relaxations and after-contractions were inhibited by the NO-synthase inhibitor NG-nitro-L-arginine (L-NNA). Thus we obtained pharmacological evidence for cholinergic muscarinic, as well as nitric oxide mediated mechanisms in the functional innervation of the oesophageal muscle.",
keywords = "Cholinergic nerves, Guinea-pig oesophagus, Human oesophagus, Nitrergic innervation",
author = "V. Halmai and {Lotfi Tabrizi}, A. and O. Horvath and L. Barth{\'o}",
year = "1996",
language = "English",
volume = "84",
pages = "291--292",
journal = "Physiology International",
issn = "2498-602X",
publisher = "Akademiai Kiado",
number = "3",

}

TY - JOUR

T1 - Pharmacological analysis of nerves supplying the oesophagus

AU - Halmai, V.

AU - Lotfi Tabrizi, A.

AU - Horvath, O.

AU - Barthó, L.

PY - 1996

Y1 - 1996

N2 - Morphological studies indicate that cholinergic, peptidergic and "nitrergic" (nitric oxide releasing) nerves supply the oesophageal muscle. In the present in vitro study, intramural nerves of guineapig and human oesophagus were activated by means of the ganglion stimulating drug nicotine and electrical field stimulation (EFS) in organ bath experiments. In general, stimulation-induced primary contractions were diminished by atropine, while non-adrenergic, non-cholinergic (NANC) relaxations and after-contractions were inhibited by the NO-synthase inhibitor NG-nitro-L-arginine (L-NNA). Thus we obtained pharmacological evidence for cholinergic muscarinic, as well as nitric oxide mediated mechanisms in the functional innervation of the oesophageal muscle.

AB - Morphological studies indicate that cholinergic, peptidergic and "nitrergic" (nitric oxide releasing) nerves supply the oesophageal muscle. In the present in vitro study, intramural nerves of guineapig and human oesophagus were activated by means of the ganglion stimulating drug nicotine and electrical field stimulation (EFS) in organ bath experiments. In general, stimulation-induced primary contractions were diminished by atropine, while non-adrenergic, non-cholinergic (NANC) relaxations and after-contractions were inhibited by the NO-synthase inhibitor NG-nitro-L-arginine (L-NNA). Thus we obtained pharmacological evidence for cholinergic muscarinic, as well as nitric oxide mediated mechanisms in the functional innervation of the oesophageal muscle.

KW - Cholinergic nerves

KW - Guinea-pig oesophagus

KW - Human oesophagus

KW - Nitrergic innervation

UR - http://www.scopus.com/inward/record.url?scp=0030322869&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0030322869&partnerID=8YFLogxK

M3 - Article

VL - 84

SP - 291

EP - 292

JO - Physiology International

JF - Physiology International

SN - 2498-602X

IS - 3

ER -