Pharmacological analysis of inhomogeneous static magnetic field-induced antinociceptive action in the mouse

K. Gyires, Z. Zádori, Bernadette Rácz, János László

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

The effect of inhomogeneous, 2-754 mT static magnetic field (SMF) on visceral pain elicited by intraperitoneal injection of 0.6% acetic acid (writhing test) was studied in the mouse. Exposure of mice to static magnetic field (permanent NdFeB N50 grade 10 mm x 10 mm cylindrical magnets with alternating poles) during the nociceptive stimulus (0-30 min) resulted in inhibition of pain reaction: the number of writhings decreased from 9 ± 2, 32 ± 4 and 30 ± 3 to 2 ± 0.03, 15 ± 1.6, and 14 ± 1.6, respectively, measured in 0-5th, 6-20th, and 21-30th min following the acetic acid challenge. The pain reaction during the total observation period was reduced by 57% (P <0.005). The analgesic action induced by SMF was inhibited by subcutaneous administration of naloxone (1 and 0.2 mg kg -1), irreversible μ-opioid receptor antagonist β-funaltrexamine (20 mg kg-1) and δ-opioid receptor antagonist naltrindole (0.5 mg kg-1), but the κ-opioid receptor antagonist norbinaltorphimine (20 mg kg-1) failed to affect the SMF-induced antinociception. In contrast to the subcutaneous administration, the intracerebroventricularly injected naloxone (10 μg mouse-1) did not antagonize the antinociceptive effect of SMF. The results suggest that acute exposure of mice to static magnetic field results in an opioid-mediated analgesic action in the writhing test in the mouse. The antinociceptive effect is likely to be mediated by μ and (to a lesser extent) δ-opioid receptors.

Original languageEnglish
Pages (from-to)456-462
Number of pages7
JournalBioelectromagnetics
Volume29
Issue number6
DOIs
Publication statusPublished - Sep 2008

Fingerprint

Magnetic Fields
magnetic fields
narcotics
Pharmacology
Narcotic Antagonists
mice
pain
antagonists
naloxone
receptors
naltrindole
analgesic effect
subcutaneous injection
analgesics
Naloxone
Acetic Acid
acetic acid
Visceral Pain
Pain
acute exposure

Keywords

  • Mouse
  • Opioid antagonists
  • Static magnetic field
  • Writhing test

ASJC Scopus subject areas

  • Agricultural and Biological Sciences (miscellaneous)
  • Biophysics

Cite this

Pharmacological analysis of inhomogeneous static magnetic field-induced antinociceptive action in the mouse. / Gyires, K.; Zádori, Z.; Rácz, Bernadette; László, János.

In: Bioelectromagnetics, Vol. 29, No. 6, 09.2008, p. 456-462.

Research output: Contribution to journalArticle

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