Pharmacological agents to aid the clinician in combating myocardial ischaemia

Research output: Contribution to journalArticle

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Abstract

This paper summarizes the effects of various drugs (sodium channel inhibitors, alpha and beta-adrenoceptor blocking agents, calcium antagonists and substances that interfere in various ways with the metabolism of arachidonic acid (e.g. aspirin, dazoxiben, nafazatrom) on the early consequences of experimental acute myocardial ischaemia. Particular attention is paid to effects on the serious early arrhythmias that arise within a few minutes of the onset of ischaemia, on those ventricular arrhythmias that result from the subsequent reperfusion of the ischaemic myocardium and on the severity and extent of myocardial ischaemic damage. From these experimental studies conclusions are drawn regarding possible approaches to early intervention with drugs in clinical myocardial infarction. Among those agents where, based on results from studies in animals, early administration should prove beneficial are beta-adrenoceptor blocking drugs, calcium antagonists, drugs that inhibit thromboxane synthesis or its effects at receptor level, agents that 'promote' prostacyclin, nitroglycerin and analgesics with marked antiarrhythmic properties (e.g. meptazinol). However, the answer to the question as to which (if any) of these drugs should be given early in clinical infarction is still dependent upon the results of considerably more experimental and clinical studies.

Original languageEnglish
Pages (from-to)91-99
Number of pages9
JournalEuropean Heart Journal
Volume4
Issue numberSuppl. D
Publication statusPublished - 1983

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Myocardial Ischemia
Pharmacology
Pharmaceutical Preparations
Adrenergic Receptors
Cardiac Arrhythmias
Meptazinol
Sodium Channel Blockers
Calcium
Thromboxanes
Nitroglycerin
Epoprostenol
Arachidonic Acid
Infarction
Aspirin
Reperfusion
Analgesics
Myocardium
Ischemia
Myocardial Infarction

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Pharmacological agents to aid the clinician in combating myocardial ischaemia. / Parratt, J.

In: European Heart Journal, Vol. 4, No. Suppl. D, 1983, p. 91-99.

Research output: Contribution to journalArticle

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