Pharmacokinetics of vinpocetine (Cavinton®) in dog

M. Polgar, L. Vereczkey

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

The pharmacokinetics of vinpocetine after 10 mg po and iv doses was studied in six beagle dogs treated in cross-over design. The concentration of the drug in plasma was determined by gas-liquid chromatography using N-P FID and capillary column. The elimination half-live and clearance values calculated from time plasma concentration data for iv administration were 8.9 ± 2.87 h and 4.2 ± 1.06 l/kg/h, respectively. The bioavailability of the drug was found to be 21.5 ± 19.3%.

Original languageEnglish
Pages (from-to)407-412
Number of pages6
JournalPolish journal of pharmacology and pharmacy
Volume36
Issue number4
Publication statusPublished - Dec 1 1984

ASJC Scopus subject areas

  • Pharmacology
  • Pharmaceutical Science

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