Pharmacokinetics of selegiline in a rabbit model

H. Kalász, K. Tekes, Zita Pöstényi, Eszter Vizvári, P. Sótonyi, D. Szabó, Edit Tóth-Molnár

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Time-dependent distribution of selegiline was monitored in various tissues of rabbits treated with a dose of 30 mg/kg intravenously. Selegiline content was determined by validated RP-HPLC method following 5,15, 30,60 and 120 minutes of treatment. The present study confirming earlier data showed that selegiline readily penetrates through the blood brain barrier, however, as a new result, high selegiline concentrations were measured in the lacrimal glands, lungs and testes as well as in the eyes of rabbits at each time point studied. When selegiline concentrations in the different eye segments were determined, a time-dependent decline of selegiline tissue levels was observed in the iris, the cornea and the intraocular lens, while the maximum level of selegiline in the retina found at 15 min and even at 60 min, was similar to that determined at 5 min following administration.

Original languageEnglish
Pages (from-to)752-756
Number of pages5
JournalLetters in Drug Design and Discovery
Volume13
Issue number8
Publication statusPublished - Oct 1 2016

Fingerprint

Selegiline
Pharmacokinetics
Rabbits
Lacrimal Apparatus
Intraocular Lenses
Iris
Blood-Brain Barrier
Cornea
Retina
Testis
High Pressure Liquid Chromatography
Lung

Keywords

  • Blood-brain penetration
  • Blood-testis penetration
  • Cornea
  • Iris
  • Pharmacokinetics
  • Rabbit
  • Retina
  • Selegiline

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmaceutical Science
  • Drug Discovery

Cite this

Pharmacokinetics of selegiline in a rabbit model. / Kalász, H.; Tekes, K.; Pöstényi, Zita; Vizvári, Eszter; Sótonyi, P.; Szabó, D.; Tóth-Molnár, Edit.

In: Letters in Drug Design and Discovery, Vol. 13, No. 8, 01.10.2016, p. 752-756.

Research output: Contribution to journalArticle

Kalász, H, Tekes, K, Pöstényi, Z, Vizvári, E, Sótonyi, P, Szabó, D & Tóth-Molnár, E 2016, 'Pharmacokinetics of selegiline in a rabbit model', Letters in Drug Design and Discovery, vol. 13, no. 8, pp. 752-756.
Kalász, H. ; Tekes, K. ; Pöstényi, Zita ; Vizvári, Eszter ; Sótonyi, P. ; Szabó, D. ; Tóth-Molnár, Edit. / Pharmacokinetics of selegiline in a rabbit model. In: Letters in Drug Design and Discovery. 2016 ; Vol. 13, No. 8. pp. 752-756.
@article{0a4e97afed624a7b8d269b557bfca2de,
title = "Pharmacokinetics of selegiline in a rabbit model",
abstract = "Time-dependent distribution of selegiline was monitored in various tissues of rabbits treated with a dose of 30 mg/kg intravenously. Selegiline content was determined by validated RP-HPLC method following 5,15, 30,60 and 120 minutes of treatment. The present study confirming earlier data showed that selegiline readily penetrates through the blood brain barrier, however, as a new result, high selegiline concentrations were measured in the lacrimal glands, lungs and testes as well as in the eyes of rabbits at each time point studied. When selegiline concentrations in the different eye segments were determined, a time-dependent decline of selegiline tissue levels was observed in the iris, the cornea and the intraocular lens, while the maximum level of selegiline in the retina found at 15 min and even at 60 min, was similar to that determined at 5 min following administration.",
keywords = "Blood-brain penetration, Blood-testis penetration, Cornea, Iris, Pharmacokinetics, Rabbit, Retina, Selegiline",
author = "H. Kal{\'a}sz and K. Tekes and Zita P{\"o}st{\'e}nyi and Eszter Vizv{\'a}ri and P. S{\'o}tonyi and D. Szab{\'o} and Edit T{\'o}th-Moln{\'a}r",
year = "2016",
month = "10",
day = "1",
language = "English",
volume = "13",
pages = "752--756",
journal = "Letters in Drug Design and Discovery",
issn = "1570-1808",
publisher = "Bentham Science Publishers B.V.",
number = "8",

}

TY - JOUR

T1 - Pharmacokinetics of selegiline in a rabbit model

AU - Kalász, H.

AU - Tekes, K.

AU - Pöstényi, Zita

AU - Vizvári, Eszter

AU - Sótonyi, P.

AU - Szabó, D.

AU - Tóth-Molnár, Edit

PY - 2016/10/1

Y1 - 2016/10/1

N2 - Time-dependent distribution of selegiline was monitored in various tissues of rabbits treated with a dose of 30 mg/kg intravenously. Selegiline content was determined by validated RP-HPLC method following 5,15, 30,60 and 120 minutes of treatment. The present study confirming earlier data showed that selegiline readily penetrates through the blood brain barrier, however, as a new result, high selegiline concentrations were measured in the lacrimal glands, lungs and testes as well as in the eyes of rabbits at each time point studied. When selegiline concentrations in the different eye segments were determined, a time-dependent decline of selegiline tissue levels was observed in the iris, the cornea and the intraocular lens, while the maximum level of selegiline in the retina found at 15 min and even at 60 min, was similar to that determined at 5 min following administration.

AB - Time-dependent distribution of selegiline was monitored in various tissues of rabbits treated with a dose of 30 mg/kg intravenously. Selegiline content was determined by validated RP-HPLC method following 5,15, 30,60 and 120 minutes of treatment. The present study confirming earlier data showed that selegiline readily penetrates through the blood brain barrier, however, as a new result, high selegiline concentrations were measured in the lacrimal glands, lungs and testes as well as in the eyes of rabbits at each time point studied. When selegiline concentrations in the different eye segments were determined, a time-dependent decline of selegiline tissue levels was observed in the iris, the cornea and the intraocular lens, while the maximum level of selegiline in the retina found at 15 min and even at 60 min, was similar to that determined at 5 min following administration.

KW - Blood-brain penetration

KW - Blood-testis penetration

KW - Cornea

KW - Iris

KW - Pharmacokinetics

KW - Rabbit

KW - Retina

KW - Selegiline

UR - http://www.scopus.com/inward/record.url?scp=84986916247&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84986916247&partnerID=8YFLogxK

M3 - Article

VL - 13

SP - 752

EP - 756

JO - Letters in Drug Design and Discovery

JF - Letters in Drug Design and Discovery

SN - 1570-1808

IS - 8

ER -