Pharmacokinetics of atracurium besylate in the pig after a single i.v. injection

C. Schopfer, J. F. Pittet, D. R. Morel, E. Tassonyi, A. Benakis

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

A pharmacokinetic study of atracurium besylate was performed in the pig after a single i.V. bolus injection of 2 mg/kg, the dose needed to produce surgical neuromuscular blockade. The plasma concentration values were obtained by high performance liquid chromatography. Using a two-compartment pharmacokinetic model, the elimination half life was found to be 28.6±6.3 min (mean ± SEM), the total volume of distribution 341+56 ml/kg and the plasma clearance 8.7+1.1 ml/min/kg. Although the doses required to obtain a satisfactory neuromuscular blockade as well as the plasma level, volume of distribution and plasma clearance values were higher in the pig than in man, the distribution and elimination half-lives were similar to those recently reported.

Original languageEnglish
Pages (from-to)299-302
Number of pages4
JournalEuropean Journal of Drug Metabolism and Pharmacokinetics
Volume14
Issue number4
DOIs
Publication statusPublished - Oct 1 1989

Keywords

  • Atracurium
  • neuromuscular relaxants
  • pharmacokinetic
  • pig

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)

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