A pharmacokinetic study of atracurium besylate was performed in the pig after a single i.V. bolus injection of 2 mg/kg, the dose needed to produce surgical neuromuscular blockade. The plasma concentration values were obtained by high performance liquid chromatography. Using a two-compartment pharmacokinetic model, the elimination half life was found to be 28.6±6.3 min (mean ± SEM), the total volume of distribution 341+56 ml/kg and the plasma clearance 8.7+1.1 ml/min/kg. Although the doses required to obtain a satisfactory neuromuscular blockade as well as the plasma level, volume of distribution and plasma clearance values were higher in the pig than in man, the distribution and elimination half-lives were similar to those recently reported.
|Number of pages||4|
|Journal||European Journal of Drug Metabolism and Pharmacokinetics|
|Publication status||Published - Oct 1 1989|
- neuromuscular relaxants
ASJC Scopus subject areas
- Pharmacology (medical)