Pharmacokinetic data on tritium labelled ethyl apovincaminate

L. Vereczkey, G. Zolyomi, L. Szporny

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Abstract

Absorption, tissue distribution and excretion of tritium labelled ethyl apovincaminate (RGH 4405, Cavinton) were studied. Both oral and i.p. administration resulted in a relatively rapid elimination of tritium activity, suggesting that neither the original drug nor its metabolites remained in the organism of rat. 50% of radioactivity was recovered in urine and 30% in faeces during 48 h. At this time only liver and kidneys contained measurable quantities of radioactivity among the organs tested. The biliary route of elimination seemed to be important, since 20% and 4% of radioactivity appeared in bile during 9 h following i.p. and p.o. administration, respectively. Enterohepatic circulation was of no consequence. Radioactivity was hardly adsorbed to or absorbed by blood cells and was almost completely bound by plasma protein(s).

Original languageEnglish
Pages (from-to)1929-1933
Number of pages5
JournalArzneimittel-Forschung/Drug Research
Volume26
Issue number10 A
Publication statusPublished - Dec 1 1976

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ASJC Scopus subject areas

  • Drug Discovery

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