Pharmacodynamic investigation of (±)-salutaridine

J. Kardos, G. Blasko, M. Simonyi, Cs Szantay

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

The alkaloid 5,6,8,14-tetradehydro-4-hydroxy-3,6-dimethoxy-17-methyl-morphinan-7-one(± )-salutaridine) was found to possess 3H-γ-aminobutryic acid (3H-GABA) displacing activity (IC50 < 1 μmol/l) in rat brain synaptic membranes. The enhancement of specific 3H-diazepam binding by increasing concentration of (±)-salutaridine follows a maximum curve, indicating (±)-salutaridine to be a partial agonist in the GABA/benzodiazepine receptor complex.

Original languageEnglish
Pages (from-to)1758-1759
Number of pages2
JournalArzneimittel-Forschung/Drug Research
Volume34
Issue number12
Publication statusPublished - Jan 1 1984

ASJC Scopus subject areas

  • Drug Discovery

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