Pharmacodynamic investigation of (±)-salutaridine

J. Kardos, G. Blasko, M. Simonyi, Cs Szantay

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

The alkaloid 5,6,8,14-tetradehydro-4-hydroxy-3,6-dimethoxy-17-methyl-morphinan-7-one(± )-salutaridine) was found to possess 3H-γ-aminobutryic acid (3H-GABA) displacing activity (IC50 <1 μmol/l) in rat brain synaptic membranes. The enhancement of specific 3H-diazepam binding by increasing concentration of (±)-salutaridine follows a maximum curve, indicating (±)-salutaridine to be a partial agonist in the GABA/benzodiazepine receptor complex.

Original languageEnglish
Pages (from-to)1758-1759
Number of pages2
JournalArzneimittel-Forschung
Volume34
Issue number12
Publication statusPublished - 1984

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Pharmacodynamics
Morphinans
Synaptic Membranes
GABA-A Receptors
Diazepam
Alkaloids
gamma-Aminobutyric Acid
Inhibitory Concentration 50
Rats
Brain
Membranes
Acids
salutaridine

ASJC Scopus subject areas

  • Chemistry(all)
  • Organic Chemistry
  • Drug Discovery
  • Pharmacology

Cite this

Pharmacodynamic investigation of (±)-salutaridine. / Kardos, J.; Blasko, G.; Simonyi, M.; Szantay, Cs.

In: Arzneimittel-Forschung, Vol. 34, No. 12, 1984, p. 1758-1759.

Research output: Contribution to journalArticle

Kardos, J, Blasko, G, Simonyi, M & Szantay, C 1984, 'Pharmacodynamic investigation of (±)-salutaridine', Arzneimittel-Forschung, vol. 34, no. 12, pp. 1758-1759.
Kardos, J. ; Blasko, G. ; Simonyi, M. ; Szantay, Cs. / Pharmacodynamic investigation of (±)-salutaridine. In: Arzneimittel-Forschung. 1984 ; Vol. 34, No. 12. pp. 1758-1759.
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