Amorf anyagok gyógyszerészeti jelentösége

Translated title of the contribution: Pharmaceutical significance of amorphous materials

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

The solid-state characteristics play an important role during the development and manufacture of medicinal products, because they may influence the effectiveness, stability as well as the processibility of pharmaceutical systems. The amorphous state is critical in determining the solid-state physical and chemical properties of many pharmaceutical dosage forms. The main reason of the growing interest toward amorphous materials is the need to improve the bioavailability of compounds with poor aqueous solubility. However the disordered structure of higher energy state assures increased solubility and faster dissolution rate, the amorphous state is a non-equilibrium state. Materials often go through spontaneous transformations towards lower energy equilibrium states.

Original languageHungarian
Pages (from-to)121-133
Number of pages13
JournalActa Pharmaceutica Hungarica
Volume78
Issue number3
Publication statusPublished - 2008

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ASJC Scopus subject areas

  • Pharmaceutical Science

Cite this

Amorf anyagok gyógyszerészeti jelentösége. / Antal, I.; Zelkó, R.

In: Acta Pharmaceutica Hungarica, Vol. 78, No. 3, 2008, p. 121-133.

Research output: Contribution to journalArticle

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