Pharmaceutical process development applying automated laboratory reactors

Tibor Chován, Imre Markovits, Béla Farkas, Kálmán Nagy, Lajos Nagy, Károly Nyíri, F. Szeifert

Research output: Contribution to journalArticle

Abstract

Application of automated laboratory reactor systems and suitable model-based approaches can speed up significantly the process development of active pharmaceutical ingredients. The paper presents the design and functions of such a reactor system including the recipe-oriented control solutions. The system performance was enhanced by implementing a model-based algorithm for estimating the process heat flow and therefore allowing the application of reaction calorimetric approaches. The application is demonstrated on two pharmaceutical process development problems. In the first, the calorimetric function was used for safety risk evaluation of a chemical reduction step. In the second, optimal process parameters of a crystallization step were determined. These examples underline that pharmaceutical and fine chemical industries can benefit from the application automated reactors and appropriate model-based methods.

Original languageEnglish
Pages (from-to)1089-1094
Number of pages6
JournalComputer Aided Chemical Engineering
Volume21
Issue numberC
DOIs
Publication statusPublished - 2006

Fingerprint

Drug products
Pharmaceutical Preparations
Chemical industry
Crystallization
Heat transfer

Keywords

  • crystallization
  • pharmaceutical industry
  • process development
  • reaction calorimetry
  • risk evaluation

ASJC Scopus subject areas

  • Chemical Engineering(all)
  • Computer Science Applications

Cite this

Pharmaceutical process development applying automated laboratory reactors. / Chován, Tibor; Markovits, Imre; Farkas, Béla; Nagy, Kálmán; Nagy, Lajos; Nyíri, Károly; Szeifert, F.

In: Computer Aided Chemical Engineering, Vol. 21, No. C, 2006, p. 1089-1094.

Research output: Contribution to journalArticle

Chován, Tibor ; Markovits, Imre ; Farkas, Béla ; Nagy, Kálmán ; Nagy, Lajos ; Nyíri, Károly ; Szeifert, F. / Pharmaceutical process development applying automated laboratory reactors. In: Computer Aided Chemical Engineering. 2006 ; Vol. 21, No. C. pp. 1089-1094.
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