Pharmaceutical applications of a bonded cyclodextrin stationary phase

Z. Juvancz, Karl Grolimund, Volker Schurig

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

Open tubular columns were coated with Chirasil‐Dex, a polysiloxane anchored permethylated β‐cyclodextrin stationary phase. A number of chiral separations of pharmaceuticals and agrichemical are presented to demonstrate the usefulness of this stationary phase in both GC and SFC. Racemates of various amines, amino acids, amino alcohols, carboxylic acids, coumarines, diols, and imides were resolved. To achieve acceptable separation of some enantiomers, a series of derivatives were studied. In many cases, cyclic derivatives and free acids gave the highest enantioselectivity.

Original languageEnglish
Pages (from-to)459-468
Number of pages10
JournalJournal of Microcolumn Separations
Volume5
Issue number5
DOIs
Publication statusPublished - 1993

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Keywords

  • capillary gas chromatography
  • Chirasil‐Dex
  • enantiomer separation
  • optimization
  • pharmaceutical applications
  • supercritical fluid chromatography

ASJC Scopus subject areas

  • Mechanical Engineering
  • Filtration and Separation

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