PHAGOZYTOSEMESSUNG AN LEUKOZYTEN VON PATIENTEN MIT MORBUS HODGKIN ODER EINEM NON-HODGKIN-LYMPHOM MIT EINER NEUEN RADIOMETRISCHEN METHODE

Translated title of the contribution: Phagocytosis measurement in Hodgkin's disease and Non-Hodgkin lymphoma-patients with a new radiometric assay

J. Suss, C. Balázs, T. Bakacs

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

A new radiometric assay for measurement of phagocytosis of opsonized Saccharomyces cerevisiae by human mononuclear cells and granulocytes is presented. This assay was based upon the incorporation of 75Se-L-selenomethionine of the extracellular yeast cells after the ingestion step without a separation procedure for intracellular and extracellular microorganisms. Therefore the assay is objective, not time consuming and convenient for clinical application. After standardization of the method, in a preliminary study phagocytosis was evaluated in 44 individuals: 16 healthy controls, 13 patients with Hodgkin's disease and 15 patients with non-Hodgkin-lymphoma before treatment. In comparison to normal controls the phagocytosis in the mononuclear cell fraction of cancer patients was increased and in granulocytes decreased. The most extensive phagocytosis activity was shown in the mononuclear cell fraction of patients with Hodgkin's disease.

Original languageGerman
Pages (from-to)56-63
Number of pages8
JournalAllergie und Immunologie
Volume28
Issue number1
Publication statusPublished - 1982

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Hodgkin Disease
Phagocytosis
Non-Hodgkin's Lymphoma
Granulocytes
Selenomethionine
Saccharomyces cerevisiae
Eating
Yeasts
Neoplasms
Therapeutics

ASJC Scopus subject areas

  • Immunology and Allergy

Cite this

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title = "PHAGOZYTOSEMESSUNG AN LEUKOZYTEN VON PATIENTEN MIT MORBUS HODGKIN ODER EINEM NON-HODGKIN-LYMPHOM MIT EINER NEUEN RADIOMETRISCHEN METHODE",
abstract = "A new radiometric assay for measurement of phagocytosis of opsonized Saccharomyces cerevisiae by human mononuclear cells and granulocytes is presented. This assay was based upon the incorporation of 75Se-L-selenomethionine of the extracellular yeast cells after the ingestion step without a separation procedure for intracellular and extracellular microorganisms. Therefore the assay is objective, not time consuming and convenient for clinical application. After standardization of the method, in a preliminary study phagocytosis was evaluated in 44 individuals: 16 healthy controls, 13 patients with Hodgkin's disease and 15 patients with non-Hodgkin-lymphoma before treatment. In comparison to normal controls the phagocytosis in the mononuclear cell fraction of cancer patients was increased and in granulocytes decreased. The most extensive phagocytosis activity was shown in the mononuclear cell fraction of patients with Hodgkin's disease.",
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T1 - PHAGOZYTOSEMESSUNG AN LEUKOZYTEN VON PATIENTEN MIT MORBUS HODGKIN ODER EINEM NON-HODGKIN-LYMPHOM MIT EINER NEUEN RADIOMETRISCHEN METHODE

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AU - Balázs, C.

AU - Bakacs, T.

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N2 - A new radiometric assay for measurement of phagocytosis of opsonized Saccharomyces cerevisiae by human mononuclear cells and granulocytes is presented. This assay was based upon the incorporation of 75Se-L-selenomethionine of the extracellular yeast cells after the ingestion step without a separation procedure for intracellular and extracellular microorganisms. Therefore the assay is objective, not time consuming and convenient for clinical application. After standardization of the method, in a preliminary study phagocytosis was evaluated in 44 individuals: 16 healthy controls, 13 patients with Hodgkin's disease and 15 patients with non-Hodgkin-lymphoma before treatment. In comparison to normal controls the phagocytosis in the mononuclear cell fraction of cancer patients was increased and in granulocytes decreased. The most extensive phagocytosis activity was shown in the mononuclear cell fraction of patients with Hodgkin's disease.

AB - A new radiometric assay for measurement of phagocytosis of opsonized Saccharomyces cerevisiae by human mononuclear cells and granulocytes is presented. This assay was based upon the incorporation of 75Se-L-selenomethionine of the extracellular yeast cells after the ingestion step without a separation procedure for intracellular and extracellular microorganisms. Therefore the assay is objective, not time consuming and convenient for clinical application. After standardization of the method, in a preliminary study phagocytosis was evaluated in 44 individuals: 16 healthy controls, 13 patients with Hodgkin's disease and 15 patients with non-Hodgkin-lymphoma before treatment. In comparison to normal controls the phagocytosis in the mononuclear cell fraction of cancer patients was increased and in granulocytes decreased. The most extensive phagocytosis activity was shown in the mononuclear cell fraction of patients with Hodgkin's disease.

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