PH- and temperature-responsive poly(aspartic acid)-l-poly(N- isopropylacrylamide) conetwork hydrogel

Árpád Némethy, Katalin Solti, L. Kiss, Benjámin Gyarmati, M. Deli, Erzsébet Csányi, A. Szilágyi

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

Multiresponsive conetwork hydrogels, PASP-l-PNIPAAm, composed of pH-responsive, biodegradable poly(aspartic acid) (PASP) and thermoresponsive poly(N-isopropylacrylamide) (PNIPAAm) were synthesized by the reaction of allylamine-grafted polysuccinimide and N-isopropylacrylamide in organic medium and a subsequent hydrolysis. The composition of allylamine-modified polymer was determined by nuclear magnetic resonance (NMR) and Fourier transformation infrared spectroscopy (FTIR). pH and temperature sensitivities were studied by measurement of swelling degrees. Scanning electron microscopic (SEM) analysis revealed that the pore size and the morphology of the PASP-l-PNIPAAm hydrogel could be controlled by the ambient pH and temperature. The volume phase transition temperature of the gels was determined by differential scanning calorimetry (DSC). A widely used non-steroidal anti-inflammatory drug, DiclofenacNa (DFS) was chosen as a model drug for drug release experiments. The hydrogel was non-toxic for human epithelial cells. According to the results these hydrogels are suitable for colon-specific controlled drug delivery.

Original languageEnglish
Pages (from-to)2392-2403
Number of pages12
JournalEuropean Polymer Journal
Volume49
Issue number9
DOIs
Publication statusPublished - Sep 2013

Fingerprint

aspartic acid
Hydrogel
Aspartic Acid
Hydrogels
drugs
Allylamine
Acids
Controlled drug delivery
Temperature
scanning
temperature
Pharmaceutical Preparations
Fourier transformation
swelling
Superconducting transition temperature
Pore size
Swelling
hydrolysis
Differential scanning calorimetry
Infrared spectroscopy

Keywords

  • Biopolymers
  • Conetwork
  • Drug delivery systems
  • Multiresponsive hydrogels
  • Poly(amino acid)
  • Poly(N- isopropylacrylamide)

ASJC Scopus subject areas

  • Polymers and Plastics
  • Physics and Astronomy(all)
  • Organic Chemistry

Cite this

PH- and temperature-responsive poly(aspartic acid)-l-poly(N- isopropylacrylamide) conetwork hydrogel. / Némethy, Árpád; Solti, Katalin; Kiss, L.; Gyarmati, Benjámin; Deli, M.; Csányi, Erzsébet; Szilágyi, A.

In: European Polymer Journal, Vol. 49, No. 9, 09.2013, p. 2392-2403.

Research output: Contribution to journalArticle

Némethy, Árpád ; Solti, Katalin ; Kiss, L. ; Gyarmati, Benjámin ; Deli, M. ; Csányi, Erzsébet ; Szilágyi, A. / PH- and temperature-responsive poly(aspartic acid)-l-poly(N- isopropylacrylamide) conetwork hydrogel. In: European Polymer Journal. 2013 ; Vol. 49, No. 9. pp. 2392-2403.
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