PGF(2α) response to the reduction of blood pressure in essential hypertension

B. Székács, E. Mohacsi, B. Gachalyi

Research output: Contribution to journalArticle

Abstract

Based on the knowledge that a blood pressure decrease provokes a blood pressure elevating long term renal response this study was designed to prove a possible role of the PGF(2α) in the maintenance of hypertension with the use of systemic blood pressure reduction. Slightly hydrated essential hypertensive patients (n = 51) were infused with a direct vasodilator, sodium nitroprusside (Nipride Roche) at rate sufficient to cause a 15% reduction in diastolic blood pressure for 5 hours, after a control period of 150 minutes. PGF(2α) level from the collected urine and plasma samples was determinated by radioimmunoassay. Only in the second period of blood pressure decrease did the excretion rate of PGF(2α) in the urine increase (characteristic of the PGF(2α) production by the kidney) compared to the control value (1264 ± 278 pg/min and 2662 ± 519 pg/min). The plasma level showed similar changes. This increased renal excretion of PGF(2α) showed a linear correlation with the reduction of mean blood pressure. The increase in renal excretion of PGF(2α) on moderate blood pressure reduction and its relationship with the blood pressure decrease suggest that renal PGF(2α) plays a significant role in the response of the kidney counterregulating the vasodilation and blood pressure reduction.

Original languageEnglish
Pages (from-to)51-52
Number of pages2
JournalIRCS Medical Science
Volume14
Issue number1
Publication statusPublished - 1986

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Blood pressure
Prostaglandins F
Blood Pressure
Kidney
Nitroprusside
Plasmas
Essential Hypertension
Urine
Vasodilator Agents
Vasodilation
Radioimmunoassay
Maintenance
Hypertension

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

PGF(2α) response to the reduction of blood pressure in essential hypertension. / Székács, B.; Mohacsi, E.; Gachalyi, B.

In: IRCS Medical Science, Vol. 14, No. 1, 1986, p. 51-52.

Research output: Contribution to journalArticle

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