PET Molecular Targets and Near-Infrared Fluorescence Imaging of Atherosclerosis

Csilla Celeng, Bart de Keizer, B. Merkely, Pim de Jong, Tim Leiner, Richard A.P. Takx

Research output: Contribution to journalReview article

3 Citations (Scopus)

Abstract

Purpose of Review: With this review, we aim to summarize the role of positron emission tomography (PET) and near-infrared fluorescence imaging (NIRF) in the detection of atherosclerosis. Recent Findings: 18F-FDG is an established measure of increased macrophage activity. However, due to its low specificity, new radiotracers have emerged for more specific detection of vascular inflammation and other high-risk plaque features such as microcalcification and neovascularization. Novel NIRF probes are engineered to sense endothelial damage as an early sign of plaque erosion as well as oxidized low-density lipoprotein (oxLDL) as a prime target for atherosclerosis. Integrated NIRF/OCT (optical coherence tomography) catheters enable to detect stent-associated microthrombi. Summary: Novel radiotracers can improve specificity of PET for imaging atherosclerosis. Advanced NIRF probes show promise for future application in human. Intravascular NIRF might play a prominent role in the detection of stent-induced vascular injury.

Original languageEnglish
Article number11
JournalCurrent Cardiology Reports
Volume20
Issue number2
DOIs
Publication statusPublished - Feb 1 2018

Fingerprint

Optical Imaging
Positron-Emission Tomography
Atherosclerosis
Stents
Calcinosis
Vascular System Injuries
Fluorodeoxyglucose F18
Optical Coherence Tomography
Blood Vessels
Catheters
Macrophages
Inflammation

Keywords

  • Atherosclerosis
  • Inflammation
  • NIRF
  • PET
  • Plaque

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

PET Molecular Targets and Near-Infrared Fluorescence Imaging of Atherosclerosis. / Celeng, Csilla; de Keizer, Bart; Merkely, B.; de Jong, Pim; Leiner, Tim; Takx, Richard A.P.

In: Current Cardiology Reports, Vol. 20, No. 2, 11, 01.02.2018.

Research output: Contribution to journalReview article

Celeng, Csilla ; de Keizer, Bart ; Merkely, B. ; de Jong, Pim ; Leiner, Tim ; Takx, Richard A.P. / PET Molecular Targets and Near-Infrared Fluorescence Imaging of Atherosclerosis. In: Current Cardiology Reports. 2018 ; Vol. 20, No. 2.
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