PET Molecular Targets and Near-Infrared Fluorescence Imaging of Atherosclerosis

Csilla Celeng, Bart de Keizer, Béla Merkely, Pim de Jong, Tim Leiner, Richard A.P. Takx

Research output: Contribution to journalReview article

7 Citations (Scopus)

Abstract

Purpose of Review: With this review, we aim to summarize the role of positron emission tomography (PET) and near-infrared fluorescence imaging (NIRF) in the detection of atherosclerosis. Recent Findings: 18F-FDG is an established measure of increased macrophage activity. However, due to its low specificity, new radiotracers have emerged for more specific detection of vascular inflammation and other high-risk plaque features such as microcalcification and neovascularization. Novel NIRF probes are engineered to sense endothelial damage as an early sign of plaque erosion as well as oxidized low-density lipoprotein (oxLDL) as a prime target for atherosclerosis. Integrated NIRF/OCT (optical coherence tomography) catheters enable to detect stent-associated microthrombi. Summary: Novel radiotracers can improve specificity of PET for imaging atherosclerosis. Advanced NIRF probes show promise for future application in human. Intravascular NIRF might play a prominent role in the detection of stent-induced vascular injury.

Original languageEnglish
Article number11
JournalCurrent Cardiology Reports
Volume20
Issue number2
DOIs
Publication statusPublished - Feb 1 2018

Keywords

  • Atherosclerosis
  • Inflammation
  • NIRF
  • PET
  • Plaque

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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