PET evaluation of a tetracyclic, atypical antidepressant, [N-methyl-11C]mianserin, in the living porcine brain

K. Marthi, D. Bender, H. Watanabe, D. F. Smith

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

We synthesized [N-methyl-11C]mianserin by alkylation of N-desmethyl mianserin with [11C]methyl iodide followed by HPLC purification. We used PET for determining the regional cerebral pharmacokinetics of the radiotracer in anesthetized swine. [N-methyl-11C]Mianserin entered most brain regions readily (range of K1 values: 0.66-1.13), reaching highest levels in the basal ganglia and thalamus. The binding potential of [N-methyl-11C]mianserin was relatively low (range: 0.07-0.50), but regional differences were nonetheless observed, with highest values in the temporal cortex and lowest values in the brainstem. These PET findings, which are the first ones for a tetracyclic, antidepressant drug, show that [N-methyl-11C]mianserin has only a limited degree of regional specificity of binding in the living brain.

Original languageEnglish
Pages (from-to)317-319
Number of pages3
JournalNuclear Medicine and Biology
Volume29
Issue number3
DOIs
Publication statusPublished - 2002

Fingerprint

Second-Generation Antidepressive Agents
Swine
Brain
Mianserin
Alkylation
Temporal Lobe
Basal Ganglia
Thalamus
Antidepressive Agents
Brain Stem
Pharmacokinetics
High Pressure Liquid Chromatography
(N-methyl)mianserin

Keywords

  • [N-methyl-C]Mianserin
  • Antidepressant
  • Brain
  • PET
  • Pharmacokinetics
  • Swine
  • Tetracyclic

ASJC Scopus subject areas

  • Cancer Research
  • Molecular Medicine
  • Radiology Nuclear Medicine and imaging

Cite this

PET evaluation of a tetracyclic, atypical antidepressant, [N-methyl-11C]mianserin, in the living porcine brain. / Marthi, K.; Bender, D.; Watanabe, H.; Smith, D. F.

In: Nuclear Medicine and Biology, Vol. 29, No. 3, 2002, p. 317-319.

Research output: Contribution to journalArticle

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