Pervaporation aided enzymatic production of glycerol monostearate in organic solvents

Z. Ziobrowski, K. Kiss, A. Rotkegel, N. Nemestóthy, R. Krupiczka, L. Gubicza

Research output: Contribution to journalArticle

14 Citations (Scopus)


In this paper the enzymatic manufacture of glycerol monostearate was studied in high polar organic solvents. Water produced during the reaction has a disadvantageous effect on the reaction rate and enzyme activity. This byproduct water was removed and the water content was kept constant using a pervaporation unit which could be integrated on-line with the reaction system. The best yield (90%) after 6 h reaction time was achieved at 40°C, at seven-fold glycerol excess using dioxane as solvent. The enzymatic esterification reaction could be described by the Random Bi-Bi mechanism. A mathematical model have been estimated and experimentally verified by a set of experiments with varying and constant water contents. The experiments both in batch and integrated system (esterification-pervaporation) could be described with good accuracy by the proposed model.

Original languageEnglish
Pages (from-to)212-217
Number of pages6
Issue number1-3
Publication statusPublished - May 31 2009


  • Esterification
  • Glycerol monostearate
  • Modeling
  • Organic solvent
  • Pervaporation

ASJC Scopus subject areas

  • Chemistry(all)
  • Chemical Engineering(all)
  • Materials Science(all)
  • Water Science and Technology
  • Mechanical Engineering

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