Perturbed Wnt signaling leads to neuronal migration delay, altered interhemispheric connections and impaired social behavior

Riccardo Bocchi, Kristof Egervari, Laura Carol-Perdiguer, Beatrice Viale, Charles Quairiaux, Mathias De Roo, Michael Boitard, Suzanne Oskouie, Patrick Salmon, J. Kiss

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Functional consequence of transient delay in neuronal migration is unclear. This study shows that Wnt/C-Kit signaling regulates radial migration in rat somatosensory cortex, and that transient delay of L2/3 neuronal migration leads to interhemispheric connectivity alteration and abnormal social behavior.

Original languageEnglish
Article number1158
JournalNature Communications
Volume8
Issue number1
DOIs
Publication statusPublished - Dec 1 2017

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Somatosensory Cortex
Social Behavior
Rats
kits
cortexes
rats

ASJC Scopus subject areas

  • Chemistry(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Physics and Astronomy(all)

Cite this

Perturbed Wnt signaling leads to neuronal migration delay, altered interhemispheric connections and impaired social behavior. / Bocchi, Riccardo; Egervari, Kristof; Carol-Perdiguer, Laura; Viale, Beatrice; Quairiaux, Charles; De Roo, Mathias; Boitard, Michael; Oskouie, Suzanne; Salmon, Patrick; Kiss, J.

In: Nature Communications, Vol. 8, No. 1, 1158, 01.12.2017.

Research output: Contribution to journalArticle

Bocchi, R, Egervari, K, Carol-Perdiguer, L, Viale, B, Quairiaux, C, De Roo, M, Boitard, M, Oskouie, S, Salmon, P & Kiss, J 2017, 'Perturbed Wnt signaling leads to neuronal migration delay, altered interhemispheric connections and impaired social behavior', Nature Communications, vol. 8, no. 1, 1158. https://doi.org/10.1038/s41467-017-01046-w
Bocchi, Riccardo ; Egervari, Kristof ; Carol-Perdiguer, Laura ; Viale, Beatrice ; Quairiaux, Charles ; De Roo, Mathias ; Boitard, Michael ; Oskouie, Suzanne ; Salmon, Patrick ; Kiss, J. / Perturbed Wnt signaling leads to neuronal migration delay, altered interhemispheric connections and impaired social behavior. In: Nature Communications. 2017 ; Vol. 8, No. 1.
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