Perturbed Wnt signaling leads to neuronal migration delay, altered interhemispheric connections and impaired social behavior

Riccardo Bocchi, Kristof Egervari, Laura Carol-Perdiguer, Beatrice Viale, Charles Quairiaux, Mathias De Roo, Michael Boitard, Suzanne Oskouie, Patrick Salmon, Jozsef Z. Kiss

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Functional consequence of transient delay in neuronal migration is unclear. This study shows that Wnt/C-Kit signaling regulates radial migration in rat somatosensory cortex, and that transient delay of L2/3 neuronal migration leads to interhemispheric connectivity alteration and abnormal social behavior.

Original languageEnglish
Article number1158
JournalNature communications
Volume8
Issue number1
DOIs
Publication statusPublished - Dec 1 2017

ASJC Scopus subject areas

  • Chemistry(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Physics and Astronomy(all)

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    Bocchi, R., Egervari, K., Carol-Perdiguer, L., Viale, B., Quairiaux, C., De Roo, M., Boitard, M., Oskouie, S., Salmon, P., & Kiss, J. Z. (2017). Perturbed Wnt signaling leads to neuronal migration delay, altered interhemispheric connections and impaired social behavior. Nature communications, 8(1), [1158]. https://doi.org/10.1038/s41467-017-01046-w