Perturbed insulin-like growth factor-1 (IGF-1) and IGF binding protein-3 are not associated with chronic widespread pain in men: Results from the European male ageing study

John McBeth, Abdelouahid Tajar, Terence W. O'Neill, Gary J. Macfarlane, Stephen R. Pye, G. Bártfai, Steven Boonen, Roger Bouillon, Felipe Casanueva, Joseph D. Finn, Gianni Forti, Aleksander Giwercman, Thang S. Han, Ilpo T. Huhtaniemi, Krzysztof Kula, Michael E J Lean, Neil Pendleton, Margus Punab, Alan J. Silman, Dirk VanderschuerenFrederick C W Wu, Luisa Petrone, Antonio Cilotti, Herman Borghs, Jolanta Slowikowska-Hilczer, Renata Walczak-Jedrzejowska, Ilpo Huhtaniemi, Frederick Wu, Alan Silman, Terence O'Neill, Joseph Finn, Philip Steer, David Lee, Stephen Pye, Marta Ocampo, Mary Lage, I. Földesi, Paul Korrovitz, Min Jiang

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Objective. To determine whether perturbations of insulin-like growth factor-1 (IGF-1) and IGF binding protein-3 (IGFBP-3) were associated with the presence of chronic widespread pain (CWP) in men. Methods. The European Male Ageing Study (EMAS) is an 8-center population-based study of men aged 40-79 years recruited from population registers. A questionnaire asked about the presence and duration of musculoskeletal pain, from which subjects reporting CWP were identified. Subjects also had an interviewer-assisted questionnaire: levels of physical activity and mood were assessed, and height and weight were measured. IGF-1 and IGFBP-3 were assayed from a fasting blood sample. Logistic regression models were used to determine the association between IGF measures and CWP. Results were expressed as odds ratios or relative risk ratios. Results. A total of 3206 subjects provided full data. Of those, 1314 (39.0%) reported no pain in the past month and 278 (8.3%) reported pain that satisfied criteria for CWP. IGF-1 concentrations were similar among subjects who reported no pain and those with CWP: 131.5 mg/l and 128.4 mg/l, respectively. This was true also for IGFBP-3 (4.3 and 4.3 mg/l). Obesity was associated with low IGF-1 and a high IGFBP-3/IGF-1 ratio, indicating less bioavailable IGF-1, irrespective of pain status. This relationship persisted after adjustment for comorbidities, depression, smoking, alcohol consumption, and quality of life. Conclusion. Overall CWP was not associated with perturbations in IGF-1 and IGFBP-3 concentrations. Hypofunctioning of the axis was noted among subjects who were obese and this was not specific to CWP. These data suggest that IGF-1 is unlikely to be etiologically important in relation to CWP, although the relationship with growth hormone remains to be elucidated. The Journal of Rheumatology

Original languageEnglish
Pages (from-to)2523-2530
Number of pages8
JournalJournal of Rheumatology
Volume36
Issue number11
DOIs
Publication statusPublished - Nov 2009

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Insulin-Like Growth Factor Binding Protein 3
Somatomedins
Chronic Pain
Pain
Logistic Models
Odds Ratio
Musculoskeletal Pain
Rheumatology
Alcohol Drinking
Growth Hormone
Registries
Comorbidity
Fasting
Obesity
Smoking
Quality of Life
Interviews
Exercise
Depression
Weights and Measures

Keywords

  • Chronic pain
  • Epidemiology
  • Insulin-like growth factor binding protein-3
  • Insulin-like growth factor-1
  • Men
  • Population study

ASJC Scopus subject areas

  • Rheumatology
  • Immunology
  • Immunology and Allergy

Cite this

Perturbed insulin-like growth factor-1 (IGF-1) and IGF binding protein-3 are not associated with chronic widespread pain in men : Results from the European male ageing study. / McBeth, John; Tajar, Abdelouahid; O'Neill, Terence W.; Macfarlane, Gary J.; Pye, Stephen R.; Bártfai, G.; Boonen, Steven; Bouillon, Roger; Casanueva, Felipe; Finn, Joseph D.; Forti, Gianni; Giwercman, Aleksander; Han, Thang S.; Huhtaniemi, Ilpo T.; Kula, Krzysztof; Lean, Michael E J; Pendleton, Neil; Punab, Margus; Silman, Alan J.; Vanderschueren, Dirk; Wu, Frederick C W; Petrone, Luisa; Cilotti, Antonio; Borghs, Herman; Slowikowska-Hilczer, Jolanta; Walczak-Jedrzejowska, Renata; Huhtaniemi, Ilpo; Wu, Frederick; Silman, Alan; O'Neill, Terence; Finn, Joseph; Steer, Philip; Lee, David; Pye, Stephen; Ocampo, Marta; Lage, Mary; Földesi, I.; Korrovitz, Paul; Jiang, Min.

In: Journal of Rheumatology, Vol. 36, No. 11, 11.2009, p. 2523-2530.

Research output: Contribution to journalArticle

McBeth, J, Tajar, A, O'Neill, TW, Macfarlane, GJ, Pye, SR, Bártfai, G, Boonen, S, Bouillon, R, Casanueva, F, Finn, JD, Forti, G, Giwercman, A, Han, TS, Huhtaniemi, IT, Kula, K, Lean, MEJ, Pendleton, N, Punab, M, Silman, AJ, Vanderschueren, D, Wu, FCW, Petrone, L, Cilotti, A, Borghs, H, Slowikowska-Hilczer, J, Walczak-Jedrzejowska, R, Huhtaniemi, I, Wu, F, Silman, A, O'Neill, T, Finn, J, Steer, P, Lee, D, Pye, S, Ocampo, M, Lage, M, Földesi, I, Korrovitz, P & Jiang, M 2009, 'Perturbed insulin-like growth factor-1 (IGF-1) and IGF binding protein-3 are not associated with chronic widespread pain in men: Results from the European male ageing study', Journal of Rheumatology, vol. 36, no. 11, pp. 2523-2530. https://doi.org/10.3899/jrheum.090113
McBeth, John ; Tajar, Abdelouahid ; O'Neill, Terence W. ; Macfarlane, Gary J. ; Pye, Stephen R. ; Bártfai, G. ; Boonen, Steven ; Bouillon, Roger ; Casanueva, Felipe ; Finn, Joseph D. ; Forti, Gianni ; Giwercman, Aleksander ; Han, Thang S. ; Huhtaniemi, Ilpo T. ; Kula, Krzysztof ; Lean, Michael E J ; Pendleton, Neil ; Punab, Margus ; Silman, Alan J. ; Vanderschueren, Dirk ; Wu, Frederick C W ; Petrone, Luisa ; Cilotti, Antonio ; Borghs, Herman ; Slowikowska-Hilczer, Jolanta ; Walczak-Jedrzejowska, Renata ; Huhtaniemi, Ilpo ; Wu, Frederick ; Silman, Alan ; O'Neill, Terence ; Finn, Joseph ; Steer, Philip ; Lee, David ; Pye, Stephen ; Ocampo, Marta ; Lage, Mary ; Földesi, I. ; Korrovitz, Paul ; Jiang, Min. / Perturbed insulin-like growth factor-1 (IGF-1) and IGF binding protein-3 are not associated with chronic widespread pain in men : Results from the European male ageing study. In: Journal of Rheumatology. 2009 ; Vol. 36, No. 11. pp. 2523-2530.
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abstract = "Objective. To determine whether perturbations of insulin-like growth factor-1 (IGF-1) and IGF binding protein-3 (IGFBP-3) were associated with the presence of chronic widespread pain (CWP) in men. Methods. The European Male Ageing Study (EMAS) is an 8-center population-based study of men aged 40-79 years recruited from population registers. A questionnaire asked about the presence and duration of musculoskeletal pain, from which subjects reporting CWP were identified. Subjects also had an interviewer-assisted questionnaire: levels of physical activity and mood were assessed, and height and weight were measured. IGF-1 and IGFBP-3 were assayed from a fasting blood sample. Logistic regression models were used to determine the association between IGF measures and CWP. Results were expressed as odds ratios or relative risk ratios. Results. A total of 3206 subjects provided full data. Of those, 1314 (39.0{\%}) reported no pain in the past month and 278 (8.3{\%}) reported pain that satisfied criteria for CWP. IGF-1 concentrations were similar among subjects who reported no pain and those with CWP: 131.5 mg/l and 128.4 mg/l, respectively. This was true also for IGFBP-3 (4.3 and 4.3 mg/l). Obesity was associated with low IGF-1 and a high IGFBP-3/IGF-1 ratio, indicating less bioavailable IGF-1, irrespective of pain status. This relationship persisted after adjustment for comorbidities, depression, smoking, alcohol consumption, and quality of life. Conclusion. Overall CWP was not associated with perturbations in IGF-1 and IGFBP-3 concentrations. Hypofunctioning of the axis was noted among subjects who were obese and this was not specific to CWP. These data suggest that IGF-1 is unlikely to be etiologically important in relation to CWP, although the relationship with growth hormone remains to be elucidated. The Journal of Rheumatology",
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TY - JOUR

T1 - Perturbed insulin-like growth factor-1 (IGF-1) and IGF binding protein-3 are not associated with chronic widespread pain in men

T2 - Results from the European male ageing study

AU - McBeth, John

AU - Tajar, Abdelouahid

AU - O'Neill, Terence W.

AU - Macfarlane, Gary J.

AU - Pye, Stephen R.

AU - Bártfai, G.

AU - Boonen, Steven

AU - Bouillon, Roger

AU - Casanueva, Felipe

AU - Finn, Joseph D.

AU - Forti, Gianni

AU - Giwercman, Aleksander

AU - Han, Thang S.

AU - Huhtaniemi, Ilpo T.

AU - Kula, Krzysztof

AU - Lean, Michael E J

AU - Pendleton, Neil

AU - Punab, Margus

AU - Silman, Alan J.

AU - Vanderschueren, Dirk

AU - Wu, Frederick C W

AU - Petrone, Luisa

AU - Cilotti, Antonio

AU - Borghs, Herman

AU - Slowikowska-Hilczer, Jolanta

AU - Walczak-Jedrzejowska, Renata

AU - Huhtaniemi, Ilpo

AU - Wu, Frederick

AU - Silman, Alan

AU - O'Neill, Terence

AU - Finn, Joseph

AU - Steer, Philip

AU - Lee, David

AU - Pye, Stephen

AU - Ocampo, Marta

AU - Lage, Mary

AU - Földesi, I.

AU - Korrovitz, Paul

AU - Jiang, Min

PY - 2009/11

Y1 - 2009/11

N2 - Objective. To determine whether perturbations of insulin-like growth factor-1 (IGF-1) and IGF binding protein-3 (IGFBP-3) were associated with the presence of chronic widespread pain (CWP) in men. Methods. The European Male Ageing Study (EMAS) is an 8-center population-based study of men aged 40-79 years recruited from population registers. A questionnaire asked about the presence and duration of musculoskeletal pain, from which subjects reporting CWP were identified. Subjects also had an interviewer-assisted questionnaire: levels of physical activity and mood were assessed, and height and weight were measured. IGF-1 and IGFBP-3 were assayed from a fasting blood sample. Logistic regression models were used to determine the association between IGF measures and CWP. Results were expressed as odds ratios or relative risk ratios. Results. A total of 3206 subjects provided full data. Of those, 1314 (39.0%) reported no pain in the past month and 278 (8.3%) reported pain that satisfied criteria for CWP. IGF-1 concentrations were similar among subjects who reported no pain and those with CWP: 131.5 mg/l and 128.4 mg/l, respectively. This was true also for IGFBP-3 (4.3 and 4.3 mg/l). Obesity was associated with low IGF-1 and a high IGFBP-3/IGF-1 ratio, indicating less bioavailable IGF-1, irrespective of pain status. This relationship persisted after adjustment for comorbidities, depression, smoking, alcohol consumption, and quality of life. Conclusion. Overall CWP was not associated with perturbations in IGF-1 and IGFBP-3 concentrations. Hypofunctioning of the axis was noted among subjects who were obese and this was not specific to CWP. These data suggest that IGF-1 is unlikely to be etiologically important in relation to CWP, although the relationship with growth hormone remains to be elucidated. The Journal of Rheumatology

AB - Objective. To determine whether perturbations of insulin-like growth factor-1 (IGF-1) and IGF binding protein-3 (IGFBP-3) were associated with the presence of chronic widespread pain (CWP) in men. Methods. The European Male Ageing Study (EMAS) is an 8-center population-based study of men aged 40-79 years recruited from population registers. A questionnaire asked about the presence and duration of musculoskeletal pain, from which subjects reporting CWP were identified. Subjects also had an interviewer-assisted questionnaire: levels of physical activity and mood were assessed, and height and weight were measured. IGF-1 and IGFBP-3 were assayed from a fasting blood sample. Logistic regression models were used to determine the association between IGF measures and CWP. Results were expressed as odds ratios or relative risk ratios. Results. A total of 3206 subjects provided full data. Of those, 1314 (39.0%) reported no pain in the past month and 278 (8.3%) reported pain that satisfied criteria for CWP. IGF-1 concentrations were similar among subjects who reported no pain and those with CWP: 131.5 mg/l and 128.4 mg/l, respectively. This was true also for IGFBP-3 (4.3 and 4.3 mg/l). Obesity was associated with low IGF-1 and a high IGFBP-3/IGF-1 ratio, indicating less bioavailable IGF-1, irrespective of pain status. This relationship persisted after adjustment for comorbidities, depression, smoking, alcohol consumption, and quality of life. Conclusion. Overall CWP was not associated with perturbations in IGF-1 and IGFBP-3 concentrations. Hypofunctioning of the axis was noted among subjects who were obese and this was not specific to CWP. These data suggest that IGF-1 is unlikely to be etiologically important in relation to CWP, although the relationship with growth hormone remains to be elucidated. The Journal of Rheumatology

KW - Chronic pain

KW - Epidemiology

KW - Insulin-like growth factor binding protein-3

KW - Insulin-like growth factor-1

KW - Men

KW - Population study

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