Perspectives of CCK antagonists in pancreatic research - Part II. Experimental studies

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4 Citations (Scopus)

Abstract

In this article, the effects of different classes of cholecystokinin (CCK) receptor antagonists in CCK-related physiological processes of the pancreas have been discussed. Both glutaramic acid derivatives and natural (benzodiazepine) analogs are potent, competitive antagonists of peripheral CCK receptors. These compounds thus provide a powerful tool for investigating the physiological and pharmacological actions of CCK in the gastrointestinal system, and have already clarified the role of CCK in pancreatic secretion and trophism or growth.

Original languageEnglish
Pages (from-to)1-8
Number of pages8
JournalInternational Journal of Pancreatology
Volume10
Issue number1
DOIs
Publication statusPublished - Sep 1991

Fingerprint

Cholecystokinin
Cholecystokinin Receptors
Research
Physiological Phenomena
Benzodiazepines
Pancreas
Pharmacology
Growth

Keywords

  • CCK antagonists
  • Cholecystokinin (CCK)
  • feedback regulation
  • pancreatic secretion and growth

ASJC Scopus subject areas

  • Oncology
  • Gastroenterology
  • Endocrinology

Cite this

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author = "T. Tak{\'a}cs and A. Pap",
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AB - In this article, the effects of different classes of cholecystokinin (CCK) receptor antagonists in CCK-related physiological processes of the pancreas have been discussed. Both glutaramic acid derivatives and natural (benzodiazepine) analogs are potent, competitive antagonists of peripheral CCK receptors. These compounds thus provide a powerful tool for investigating the physiological and pharmacological actions of CCK in the gastrointestinal system, and have already clarified the role of CCK in pancreatic secretion and trophism or growth.

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KW - pancreatic secretion and growth

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