Personalized laboratory medicine: A patient-centered future approach

Irena Prodan Žitnik, Darko Černe, Irene Mancini, Lisa Simi, Mario Pazzagli, Chiara Di Resta, Helena Podgornik, Barbka Repič Lampret, Katarina Trebušak Podkrajšek, C. Sipeky, Ron Van Schaik, Ivan Brandslund, Pieter Vermeersch, Matthias Schwab, Janja Marc

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

In contrast to population-based medical decision making, which emphasizes the use of evidence-based treatment strategies for groups of patients, personalized medicine is based on optimizing treatment at the level of the individual patient. The creation of molecular profiles of individual patients was made possible by the advent of "omics" technologies, based on high throughput instrumental techniques in combination with biostatistics tools and artificial intelligence. The goal of personalized laboratory medicine is to use advanced technologies in the process of preventive, curative or palliative patient management. Personalized medicine does not rely on changes in concentration of a single molecular marker to make a therapeutic decision, but rather on changes of a profile of markers characterizing an individual patient's status, taking into account not only the expected response to treatment of the disease but also the expected response of the patient. Such medical approach promises a more effective diagnostics with more effective and safer treatment, as well as faster recovery and restoration of health and improved cost effectiveness. The laboratory medicine profession is aware of its key role in personalized medicine, but to empower the laboratories, at least an enhancement in cooperation between disciplines within laboratory medicine will be necessary.

Original languageEnglish
JournalClinical Chemistry and Laboratory Medicine
DOIs
Publication statusAccepted/In press - Jul 10 2018

    Fingerprint

Keywords

  • advanced omics technologies
  • diagnostic marker
  • genome
  • metabolome
  • molecular profiling
  • proteome
  • transcriptome

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Biochemistry, medical

Cite this

Prodan Žitnik, I., Černe, D., Mancini, I., Simi, L., Pazzagli, M., Di Resta, C., Podgornik, H., Repič Lampret, B., Trebušak Podkrajšek, K., Sipeky, C., Van Schaik, R., Brandslund, I., Vermeersch, P., Schwab, M., & Marc, J. (Accepted/In press). Personalized laboratory medicine: A patient-centered future approach. Clinical Chemistry and Laboratory Medicine. https://doi.org/10.1515/cclm-2018-0181