Personalized laboratory medicine: A patient-centered future approach

Irena Prodan Žitnik, Darko Černe, Irene Mancini, Lisa Simi, Mario Pazzagli, Chiara Di Resta, Helena Podgornik, Barbka Repič Lampret, Katarina Trebušak Podkrajšek, C. Sipeky, Ron Van Schaik, Ivan Brandslund, Pieter Vermeersch, Matthias Schwab, Janja Marc

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

In contrast to population-based medical decision making, which emphasizes the use of evidence-based treatment strategies for groups of patients, personalized medicine is based on optimizing treatment at the level of the individual patient. The creation of molecular profiles of individual patients was made possible by the advent of "omics" technologies, based on high throughput instrumental techniques in combination with biostatistics tools and artificial intelligence. The goal of personalized laboratory medicine is to use advanced technologies in the process of preventive, curative or palliative patient management. Personalized medicine does not rely on changes in concentration of a single molecular marker to make a therapeutic decision, but rather on changes of a profile of markers characterizing an individual patient's status, taking into account not only the expected response to treatment of the disease but also the expected response of the patient. Such medical approach promises a more effective diagnostics with more effective and safer treatment, as well as faster recovery and restoration of health and improved cost effectiveness. The laboratory medicine profession is aware of its key role in personalized medicine, but to empower the laboratories, at least an enhancement in cooperation between disciplines within laboratory medicine will be necessary.

Original languageEnglish
JournalClinical Chemistry and Laboratory Medicine
DOIs
Publication statusAccepted/In press - Jul 10 2018

Fingerprint

Precision Medicine
Medicine
Biostatistics
Technology
Therapeutics
Artificial Intelligence
Cost effectiveness
Health Care Costs
Restoration
Cost-Benefit Analysis
Artificial intelligence
Decision making
Throughput
Health
Recovery
Population

Keywords

  • advanced omics technologies
  • diagnostic marker
  • genome
  • metabolome
  • molecular profiling
  • proteome
  • transcriptome

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Biochemistry, medical

Cite this

Prodan Žitnik, I., Černe, D., Mancini, I., Simi, L., Pazzagli, M., Di Resta, C., ... Marc, J. (Accepted/In press). Personalized laboratory medicine: A patient-centered future approach. Clinical Chemistry and Laboratory Medicine. https://doi.org/10.1515/cclm-2018-0181

Personalized laboratory medicine : A patient-centered future approach. / Prodan Žitnik, Irena; Černe, Darko; Mancini, Irene; Simi, Lisa; Pazzagli, Mario; Di Resta, Chiara; Podgornik, Helena; Repič Lampret, Barbka; Trebušak Podkrajšek, Katarina; Sipeky, C.; Van Schaik, Ron; Brandslund, Ivan; Vermeersch, Pieter; Schwab, Matthias; Marc, Janja.

In: Clinical Chemistry and Laboratory Medicine, 10.07.2018.

Research output: Contribution to journalArticle

Prodan Žitnik, I, Černe, D, Mancini, I, Simi, L, Pazzagli, M, Di Resta, C, Podgornik, H, Repič Lampret, B, Trebušak Podkrajšek, K, Sipeky, C, Van Schaik, R, Brandslund, I, Vermeersch, P, Schwab, M & Marc, J 2018, 'Personalized laboratory medicine: A patient-centered future approach', Clinical Chemistry and Laboratory Medicine. https://doi.org/10.1515/cclm-2018-0181
Prodan Žitnik, Irena ; Černe, Darko ; Mancini, Irene ; Simi, Lisa ; Pazzagli, Mario ; Di Resta, Chiara ; Podgornik, Helena ; Repič Lampret, Barbka ; Trebušak Podkrajšek, Katarina ; Sipeky, C. ; Van Schaik, Ron ; Brandslund, Ivan ; Vermeersch, Pieter ; Schwab, Matthias ; Marc, Janja. / Personalized laboratory medicine : A patient-centered future approach. In: Clinical Chemistry and Laboratory Medicine. 2018.
@article{849973a256534b3d95b564268850ef80,
title = "Personalized laboratory medicine: A patient-centered future approach",
abstract = "In contrast to population-based medical decision making, which emphasizes the use of evidence-based treatment strategies for groups of patients, personalized medicine is based on optimizing treatment at the level of the individual patient. The creation of molecular profiles of individual patients was made possible by the advent of {"}omics{"} technologies, based on high throughput instrumental techniques in combination with biostatistics tools and artificial intelligence. The goal of personalized laboratory medicine is to use advanced technologies in the process of preventive, curative or palliative patient management. Personalized medicine does not rely on changes in concentration of a single molecular marker to make a therapeutic decision, but rather on changes of a profile of markers characterizing an individual patient's status, taking into account not only the expected response to treatment of the disease but also the expected response of the patient. Such medical approach promises a more effective diagnostics with more effective and safer treatment, as well as faster recovery and restoration of health and improved cost effectiveness. The laboratory medicine profession is aware of its key role in personalized medicine, but to empower the laboratories, at least an enhancement in cooperation between disciplines within laboratory medicine will be necessary.",
keywords = "advanced omics technologies, diagnostic marker, genome, metabolome, molecular profiling, proteome, transcriptome",
author = "{Prodan Žitnik}, Irena and Darko Černe and Irene Mancini and Lisa Simi and Mario Pazzagli and {Di Resta}, Chiara and Helena Podgornik and {Repič Lampret}, Barbka and {Trebušak Podkrajšek}, Katarina and C. Sipeky and {Van Schaik}, Ron and Ivan Brandslund and Pieter Vermeersch and Matthias Schwab and Janja Marc",
year = "2018",
month = "7",
day = "10",
doi = "10.1515/cclm-2018-0181",
language = "English",
journal = "Clinical Chemistry and Laboratory Medicine",
issn = "1434-6621",
publisher = "Walter de Gruyter GmbH & Co. KG",

}

TY - JOUR

T1 - Personalized laboratory medicine

T2 - A patient-centered future approach

AU - Prodan Žitnik, Irena

AU - Černe, Darko

AU - Mancini, Irene

AU - Simi, Lisa

AU - Pazzagli, Mario

AU - Di Resta, Chiara

AU - Podgornik, Helena

AU - Repič Lampret, Barbka

AU - Trebušak Podkrajšek, Katarina

AU - Sipeky, C.

AU - Van Schaik, Ron

AU - Brandslund, Ivan

AU - Vermeersch, Pieter

AU - Schwab, Matthias

AU - Marc, Janja

PY - 2018/7/10

Y1 - 2018/7/10

N2 - In contrast to population-based medical decision making, which emphasizes the use of evidence-based treatment strategies for groups of patients, personalized medicine is based on optimizing treatment at the level of the individual patient. The creation of molecular profiles of individual patients was made possible by the advent of "omics" technologies, based on high throughput instrumental techniques in combination with biostatistics tools and artificial intelligence. The goal of personalized laboratory medicine is to use advanced technologies in the process of preventive, curative or palliative patient management. Personalized medicine does not rely on changes in concentration of a single molecular marker to make a therapeutic decision, but rather on changes of a profile of markers characterizing an individual patient's status, taking into account not only the expected response to treatment of the disease but also the expected response of the patient. Such medical approach promises a more effective diagnostics with more effective and safer treatment, as well as faster recovery and restoration of health and improved cost effectiveness. The laboratory medicine profession is aware of its key role in personalized medicine, but to empower the laboratories, at least an enhancement in cooperation between disciplines within laboratory medicine will be necessary.

AB - In contrast to population-based medical decision making, which emphasizes the use of evidence-based treatment strategies for groups of patients, personalized medicine is based on optimizing treatment at the level of the individual patient. The creation of molecular profiles of individual patients was made possible by the advent of "omics" technologies, based on high throughput instrumental techniques in combination with biostatistics tools and artificial intelligence. The goal of personalized laboratory medicine is to use advanced technologies in the process of preventive, curative or palliative patient management. Personalized medicine does not rely on changes in concentration of a single molecular marker to make a therapeutic decision, but rather on changes of a profile of markers characterizing an individual patient's status, taking into account not only the expected response to treatment of the disease but also the expected response of the patient. Such medical approach promises a more effective diagnostics with more effective and safer treatment, as well as faster recovery and restoration of health and improved cost effectiveness. The laboratory medicine profession is aware of its key role in personalized medicine, but to empower the laboratories, at least an enhancement in cooperation between disciplines within laboratory medicine will be necessary.

KW - advanced omics technologies

KW - diagnostic marker

KW - genome

KW - metabolome

KW - molecular profiling

KW - proteome

KW - transcriptome

UR - http://www.scopus.com/inward/record.url?scp=85050101755&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85050101755&partnerID=8YFLogxK

U2 - 10.1515/cclm-2018-0181

DO - 10.1515/cclm-2018-0181

M3 - Article

C2 - 29990304

AN - SCOPUS:85050101755

JO - Clinical Chemistry and Laboratory Medicine

JF - Clinical Chemistry and Laboratory Medicine

SN - 1434-6621

ER -