Persistent sodium current is a target for cAMP-induced neuronal plasticity in a state-setting modulatory interneuron

E. S. Nikitin, T. Kiss, K. Staras, M. O'Shea, P. R. Benjamin, G. Kemenes

Research output: Contribution to journalArticle

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Abstract

We have identified a TTX-resistant low-threshold persistent inward sodium current in the cerebral giant cells (CGCs) of Lymnaea, an important state-setting modulatory cell type of molluscan feeding networks. This current has slow voltage-dependent activation and de-activation kinetics, ultra-slow inactivation kinetics and fast de-inactivation kinetics. It activates at approximately -90 mV, peaks at approximately -30 mV, reverses at approximately +35 mV and does not show full voltage-dependent inactivation even at positive voltage steps. Lithium-sodium replacement experiments indicate that the persistent sodium current makes a significant contribution to the CGC membrane potential. Injection of cyclic adenosine monophosphate (cAMP) into the CGC cell body produces a large increase in the persistent sodium current that lasts for several hours. cAMP injection also leads to increased bursting, a significant decrease in the resistance and a significant depolarization of the soma membrane, indicating that cAMP-dependent mechanisms induce prolonged neuronal plasticity in the CGCs. Our observations provide the first link between cAMP-mediated modulation of a TTX-resistant persistent sodium current and prolonged neuronal plasticity in an identified modulatory cell type that plays an important role in behavioral state setting.

Original languageEnglish
Pages (from-to)453-463
Number of pages11
JournalJournal of Neurophysiology
Volume95
Issue number1
DOIs
Publication statusPublished - Jan 2006

Fingerprint

Neuronal Plasticity
Interneurons
Cyclic AMP
Giant Cells
Sodium
Lymnaea
Injections
Carisoprodol
Lithium
Membrane Potentials
Cell Membrane
Membranes

ASJC Scopus subject areas

  • Physiology
  • Neuroscience(all)

Cite this

Persistent sodium current is a target for cAMP-induced neuronal plasticity in a state-setting modulatory interneuron. / Nikitin, E. S.; Kiss, T.; Staras, K.; O'Shea, M.; Benjamin, P. R.; Kemenes, G.

In: Journal of Neurophysiology, Vol. 95, No. 1, 01.2006, p. 453-463.

Research output: Contribution to journalArticle

Nikitin, E. S. ; Kiss, T. ; Staras, K. ; O'Shea, M. ; Benjamin, P. R. ; Kemenes, G. / Persistent sodium current is a target for cAMP-induced neuronal plasticity in a state-setting modulatory interneuron. In: Journal of Neurophysiology. 2006 ; Vol. 95, No. 1. pp. 453-463.
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